Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy
The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation. This was a p...
Gespeichert in:
| Veröffentlicht in: | Journal of the Turkish German Gynecological Association 2021-05, Vol.22 (2), p.127-131 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 131 |
|---|---|
| container_issue | 2 |
| container_start_page | 127 |
| container_title | Journal of the Turkish German Gynecological Association |
| container_volume | 22 |
| creator | Şimşek Tanin, Özlem Kara, Mustafa Engin-Üstün, Yaprak Göçmen, Ayşe Yeşim Yalvaç, Ethem Serdar |
| description | The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation.
This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age.
The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p |
| doi_str_mv | 10.4274/jtgga.galenos.2020.2020.0051 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8187971</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2540332071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-f423f5e53e550d684f9403464846da08ce62dc1fd3df88971344ead0df3934b33</originalsourceid><addsrcrecordid>eNpVkVFrHCEUhaW0NGGTv1AG2oe-7EZH3VEohbBN28BCX5LXiqvXqcHVqc4E8u8zs7PdJi9X8Z5zOPIh9IngFasbdvXQt61etTpATGVV4xrPA2NO3qBzQrFcYirw29NdyjN0WYrfYcYaxqWk79EZrTlpGOXn6Pcm7TudfUmxSq5qw2BSgcpCm7XVvR-fu5zsYPpKR1tlMND1KVcBHiGUysfKer2D3pvDPqa812G0QBt1NE8X6J3TocDl8Vyg--83d5ufy-2vH7eb6-3SMEn7pWM1dRw4Bc6xXQvmJMOUrZlga6uxMLCurSHOUuuEkA2hjIG22DoqKdtRukBf59xu2O3BGoh91kF12e91flJJe_V6E_0f1aZHJYhoprwF-ngMyOnvAKVXD2nIceysaj52oTU-qD7PKm9BhxSDj_BfePvt5nqrCK8FmaRfZqnJqZQM7lSGYDWxVAeW6shSTRjnMbEc7R9efuhk_keOPgMUzKBh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2540332071</pqid></control><display><type>article</type><title>Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Şimşek Tanin, Özlem ; Kara, Mustafa ; Engin-Üstün, Yaprak ; Göçmen, Ayşe Yeşim ; Yalvaç, Ethem Serdar</creator><contributor>Ünlü,Cihat</contributor><creatorcontrib>Şimşek Tanin, Özlem ; Kara, Mustafa ; Engin-Üstün, Yaprak ; Göçmen, Ayşe Yeşim ; Yalvaç, Ethem Serdar ; Ünlü,Cihat</creatorcontrib><description>The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation.
This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age.
The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p<0.001).
In this study the use of AGEs, CML, and RAGE/AGER concentrations for the diagnosis and screening of gestational diabetes was investigated. It was found that advanced glycation products were significantly elevated in pregnancies with both IGT and GDM. These biochemical markers of glucose homeostasis dysregulation may have potential for GDM screening in the future.</description><identifier>ISSN: 1309-0399</identifier><identifier>EISSN: 1309-0380</identifier><identifier>DOI: 10.4274/jtgga.galenos.2020.2020.0051</identifier><identifier>PMID: 32517435</identifier><language>eng</language><publisher>Turkey: Turkish-German Gynecological Association</publisher><subject>Biochemistry ; Blood pressure ; Body mass index ; Fasting ; Gestational diabetes ; Glucose ; Homeostasis ; Investigations ; Metabolism ; Metabolites ; Morbidity ; Mortality ; Original Investigation ; Pregnancy ; Statistical analysis ; Tıp ; Womens health</subject><ispartof>Journal of the Turkish German Gynecological Association, 2021-05, Vol.22 (2), p.127-131</ispartof><rights>2021. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at http://www.jtgga.org/copyright</rights><rights>Copyright 2021 by the Turkish-German Gynecological Education and Research Foundation 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-f423f5e53e550d684f9403464846da08ce62dc1fd3df88971344ead0df3934b33</citedby><orcidid>0000-0001-9941-4999 ; 0000-0003-2282-6850 ; 0000-0002-4036-5640 ; 0000-0001-6406-5012 ; 0000-0002-1011-3848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187971/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187971/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32517435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ünlü,Cihat</contributor><creatorcontrib>Şimşek Tanin, Özlem</creatorcontrib><creatorcontrib>Kara, Mustafa</creatorcontrib><creatorcontrib>Engin-Üstün, Yaprak</creatorcontrib><creatorcontrib>Göçmen, Ayşe Yeşim</creatorcontrib><creatorcontrib>Yalvaç, Ethem Serdar</creatorcontrib><title>Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy</title><title>Journal of the Turkish German Gynecological Association</title><addtitle>J Turk Ger Gynecol Assoc</addtitle><description>The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation.
This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age.
The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p<0.001).
In this study the use of AGEs, CML, and RAGE/AGER concentrations for the diagnosis and screening of gestational diabetes was investigated. It was found that advanced glycation products were significantly elevated in pregnancies with both IGT and GDM. These biochemical markers of glucose homeostasis dysregulation may have potential for GDM screening in the future.</description><subject>Biochemistry</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Fasting</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Investigations</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Original Investigation</subject><subject>Pregnancy</subject><subject>Statistical analysis</subject><subject>Tıp</subject><subject>Womens health</subject><issn>1309-0399</issn><issn>1309-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkVFrHCEUhaW0NGGTv1AG2oe-7EZH3VEohbBN28BCX5LXiqvXqcHVqc4E8u8zs7PdJi9X8Z5zOPIh9IngFasbdvXQt61etTpATGVV4xrPA2NO3qBzQrFcYirw29NdyjN0WYrfYcYaxqWk79EZrTlpGOXn6Pcm7TudfUmxSq5qw2BSgcpCm7XVvR-fu5zsYPpKR1tlMND1KVcBHiGUysfKer2D3pvDPqa812G0QBt1NE8X6J3TocDl8Vyg--83d5ufy-2vH7eb6-3SMEn7pWM1dRw4Bc6xXQvmJMOUrZlga6uxMLCurSHOUuuEkA2hjIG22DoqKdtRukBf59xu2O3BGoh91kF12e91flJJe_V6E_0f1aZHJYhoprwF-ngMyOnvAKVXD2nIceysaj52oTU-qD7PKm9BhxSDj_BfePvt5nqrCK8FmaRfZqnJqZQM7lSGYDWxVAeW6shSTRjnMbEc7R9efuhk_keOPgMUzKBh</recordid><startdate>20210528</startdate><enddate>20210528</enddate><creator>Şimşek Tanin, Özlem</creator><creator>Kara, Mustafa</creator><creator>Engin-Üstün, Yaprak</creator><creator>Göçmen, Ayşe Yeşim</creator><creator>Yalvaç, Ethem Serdar</creator><general>Turkish-German Gynecological Association</general><general>Galenos Publishing House</general><general>Galenos Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IEBAR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9941-4999</orcidid><orcidid>https://orcid.org/0000-0003-2282-6850</orcidid><orcidid>https://orcid.org/0000-0002-4036-5640</orcidid><orcidid>https://orcid.org/0000-0001-6406-5012</orcidid><orcidid>https://orcid.org/0000-0002-1011-3848</orcidid></search><sort><creationdate>20210528</creationdate><title>Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy</title><author>Şimşek Tanin, Özlem ; Kara, Mustafa ; Engin-Üstün, Yaprak ; Göçmen, Ayşe Yeşim ; Yalvaç, Ethem Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-f423f5e53e550d684f9403464846da08ce62dc1fd3df88971344ead0df3934b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biochemistry</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Fasting</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Investigations</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Original Investigation</topic><topic>Pregnancy</topic><topic>Statistical analysis</topic><topic>Tıp</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şimşek Tanin, Özlem</creatorcontrib><creatorcontrib>Kara, Mustafa</creatorcontrib><creatorcontrib>Engin-Üstün, Yaprak</creatorcontrib><creatorcontrib>Göçmen, Ayşe Yeşim</creatorcontrib><creatorcontrib>Yalvaç, Ethem Serdar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Idealonline online kütüphane - Journals</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Turkish German Gynecological Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şimşek Tanin, Özlem</au><au>Kara, Mustafa</au><au>Engin-Üstün, Yaprak</au><au>Göçmen, Ayşe Yeşim</au><au>Yalvaç, Ethem Serdar</au><au>Ünlü,Cihat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy</atitle><jtitle>Journal of the Turkish German Gynecological Association</jtitle><addtitle>J Turk Ger Gynecol Assoc</addtitle><date>2021-05-28</date><risdate>2021</risdate><volume>22</volume><issue>2</issue><spage>127</spage><epage>131</epage><pages>127-131</pages><issn>1309-0399</issn><eissn>1309-0380</eissn><abstract>The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation.
This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age.
The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p<0.001).
In this study the use of AGEs, CML, and RAGE/AGER concentrations for the diagnosis and screening of gestational diabetes was investigated. It was found that advanced glycation products were significantly elevated in pregnancies with both IGT and GDM. These biochemical markers of glucose homeostasis dysregulation may have potential for GDM screening in the future.</abstract><cop>Turkey</cop><pub>Turkish-German Gynecological Association</pub><pmid>32517435</pmid><doi>10.4274/jtgga.galenos.2020.2020.0051</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9941-4999</orcidid><orcidid>https://orcid.org/0000-0003-2282-6850</orcidid><orcidid>https://orcid.org/0000-0002-4036-5640</orcidid><orcidid>https://orcid.org/0000-0001-6406-5012</orcidid><orcidid>https://orcid.org/0000-0002-1011-3848</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1309-0399 |
| ispartof | Journal of the Turkish German Gynecological Association, 2021-05, Vol.22 (2), p.127-131 |
| issn | 1309-0399 1309-0380 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8187971 |
| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biochemistry Blood pressure Body mass index Fasting Gestational diabetes Glucose Homeostasis Investigations Metabolism Metabolites Morbidity Mortality Original Investigation Pregnancy Statistical analysis Tıp Womens health |
| title | Comparison of glucose degradation product and receptor levels in diabetic and normal pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T05%3A22%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20glucose%20degradation%20product%20and%20receptor%20levels%20in%20diabetic%20and%20normal%20pregnancy&rft.jtitle=Journal%20of%20the%20Turkish%20German%20Gynecological%20Association&rft.au=%C5%9Eim%C5%9Fek%20Tanin,%20%C3%96zlem&rft.date=2021-05-28&rft.volume=22&rft.issue=2&rft.spage=127&rft.epage=131&rft.pages=127-131&rft.issn=1309-0399&rft.eissn=1309-0380&rft_id=info:doi/10.4274/jtgga.galenos.2020.2020.0051&rft_dat=%3Cproquest_pubme%3E2540332071%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2540332071&rft_id=info:pmid/32517435&rfr_iscdi=true |