Unifying the Aminohexopyranose‐ and Peptidyl‐Nucleoside Antibiotics: Implications for Antibiotic Design

In search of new anti‐tuberculars compatible with anti‐retroviral therapy we re‐identified amicetin as a lead compound. Amicetin's binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously determined by crystallography and reveals it to occupy the peptidyl transf...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-07, Vol.59 (28), p.11330-11333
Hauptverfasser:	Serrano, Catherine M., Kanna Reddy, Hariprasada Reddy, Eiler, Daniel, Koch, Michael, Tresco, Ben I. C., Barrows, Louis R., VanderLinden, Ryan T., Testa, Charles A., Sebahar, Paul R., Looper, Ryan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	amicetin Animals antibiotic Antibiotics Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Binding sites blasticdin S Chemistry Chemistry, Multidisciplinary Chlorocebus aethiops Crystallography Crystallography, X-Ray Drug Design Humans Lead compounds Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Natural products Peptides - chemistry Physical Sciences Protein biosynthesis Protein synthesis Pyrans - chemistry Pyrimidine Nucleosides - chemistry ribosome Science & Technology Selectivity Thermus thermophilus - chemistry THP-1 Cells Translation translation inhibitor Vero Cells
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