Glymphatic failure as a final common pathway to dementia
Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2020-10, Vol.370 (6512), p.50-56 |
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| creator | Nedergaard, Maiken Goldman, Steven A |
| description | Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway. |
| doi_str_mv | 10.1126/science.abb8739 |
| format | Article |
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The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.</description><subject>Aging</subject><subject>Alzheimer Disease - etiology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Animals</subject><subject>Aquaporin 4 - genetics</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Glymphatic System - physiopathology</subject><subject>Humans</subject><subject>Lymphatic System - physiopathology</subject><subject>Mice</subject><subject>Polymorphism, Genetic</subject><subject>Prion Proteins - metabolism</subject><subject>Protein Aggregates</subject><subject>Sleep</subject><subject>Sleep Wake Disorders - complications</subject><subject>Sleep Wake Disorders - physiopathology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9LwzAUx4Mobk7P3qRHL91emqRJLoIMncLAi55DmiYu0ja1aZX991asQ0_v8P31-CB0iWGJcZavovG2MXapi0JwIo_QHINkqcyAHKM5AMlTAZzN0FmMbwCjJskpmhECQBmGORKbal-3O917kzjtq6GziY6JTpxvdJWYUNehSVrd7z71PulDUtraNr3X5-jE6Srai-ku0Mv93fP6Id0-bR7Xt9vUUCb7lJWF1FxykuPCFoZgJrTDnMm8BMcszTnmgrISc8sdERwcyanhFLDJstJgskA3P73tUNS2NON4pyvVdr7W3V4F7dV_pfE79Ro-lMAiZzQbC66ngi68Dzb2qvbR2KrSjQ1DVBmlgkIGWI7W1Y_VdCHGzrrDDAb1zVtNvNXEe0xc_f3u4P8FTL4AmPp-CA</recordid><startdate>20201002</startdate><enddate>20201002</enddate><creator>Nedergaard, Maiken</creator><creator>Goldman, Steven A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5498-4303</orcidid><orcidid>https://orcid.org/0000-0002-9254-5360</orcidid></search><sort><creationdate>20201002</creationdate><title>Glymphatic failure as a final common pathway to dementia</title><author>Nedergaard, Maiken ; Goldman, Steven A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-5db9a797361bebc3158af17596d0f5e46717845d17e7f3870f364c7401c22dc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aging</topic><topic>Alzheimer Disease - etiology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Animals</topic><topic>Aquaporin 4 - genetics</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Glymphatic System - physiopathology</topic><topic>Humans</topic><topic>Lymphatic System - physiopathology</topic><topic>Mice</topic><topic>Polymorphism, Genetic</topic><topic>Prion Proteins - metabolism</topic><topic>Protein Aggregates</topic><topic>Sleep</topic><topic>Sleep Wake Disorders - complications</topic><topic>Sleep Wake Disorders - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nedergaard, Maiken</creatorcontrib><creatorcontrib>Goldman, Steven A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nedergaard, Maiken</au><au>Goldman, Steven A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glymphatic failure as a final common pathway to dementia</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2020-10-02</date><risdate>2020</risdate><volume>370</volume><issue>6512</issue><spage>50</spage><epage>56</epage><pages>50-56</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. 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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2020-10, Vol.370 (6512), p.50-56 |
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| language | eng |
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| source | MEDLINE; Science Magazine |
| subjects | Aging Alzheimer Disease - etiology Alzheimer Disease - physiopathology Animals Aquaporin 4 - genetics Cardiovascular Diseases - etiology Glymphatic System - physiopathology Humans Lymphatic System - physiopathology Mice Polymorphism, Genetic Prion Proteins - metabolism Protein Aggregates Sleep Sleep Wake Disorders - complications Sleep Wake Disorders - physiopathology |
| title | Glymphatic failure as a final common pathway to dementia |
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