An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia

Aggressive myeloid leukemias such as blast crisis chronic myeloid leukemia and acute myeloid leukemia remain highly lethal. Here we report a genome-wide in vivo CRISPR screen to identify new dependencies in this disease. Among these, RNA-binding proteins (RBPs) in general, and the double-stranded RB...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature cancer 2020-04, Vol.1 (4), p.410-422
Hauptverfasser:	Bajaj, Jeevisha, Hamilton, Michael, Shima, Yutaka, Chambers, Kendall, Spinler, Kyle, Van Nostrand, Eric L, Yee, Brian A, Blue, Steven M, Chen, Michael, Rizzeri, David, Chuah, Charles, Oehler, Vivian G, Broome, H Elizabeth, Sasik, Roman, Scott-Browne, James, Rao, Anjana, Yeo, Gene W, Reya, Tannishtha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blast Crisis Clustered Regularly Interspaced Short Palindromic Repeats - genetics Genome Leukemia, Myeloid, Acute - genetics Mice Nerve Tissue Proteins - genetics RNA-Binding Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!