mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet

Natural killer (NK) cell development is a multistep process that requires a variety of signals and transcription factors. The lack of mammalian target of rapamycin (mTOR) kinase severely impairs NK cell development in mice. mTOR binds to Raptor and Rictor to form two complexes, mTORC1 and mTORC2, re...

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Veröffentlicht in:	Cell death and differentiation 2021-06, Vol.28 (6), p.1900-1909
Hauptverfasser:	Li, Dan, Wang, Yuande, Yang, Meixiang, Dong, Zhongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/21 13/31 631/250 631/250/1933 Animals Apoptosis Basic-Leucine Zipper Transcription Factors - metabolism Biochemistry Biomedical and Life Sciences CD11b antigen CD122 antigen CD27 antigen Cell Biology Cell Cycle Analysis Cell Differentiation Clonal deletion Humans Killer Cells, Natural - metabolism Kinases Life Sciences Mechanistic Target of Rapamycin Complex 1 - metabolism Mechanistic Target of Rapamycin Complex 2 - metabolism Mice Mushrooms Natural killer cells Rapamycin Stem Cells T-Box Domain Proteins - metabolism TOR protein Transcription factors
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