Differences in the clinicopathological features of pancreatic head carcinoma in dorsal and ventral pancreas: A single institution retrospective review
The embryonic development of the pancreas originates from dorsal and ventral anlagen, and the pancreatic cancer arising from dorsal or ventral pancreas may have different clinical pathology features. This study aims to explore whether there are differences in clinicopathological features and prognos...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-06, Vol.100 (22), p.e26167-e26167 |
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| creator | Wang, Dasong Zeng, Qihui Niu, Xiaoya Chen, Xinghan Ye, Hui |
| description | The embryonic development of the pancreas originates from dorsal and ventral anlagen, and the pancreatic cancer arising from dorsal or ventral pancreas may have different clinical pathology features. This study aims to explore whether there are differences in clinicopathological features and prognosis of pancreatic head carcinoma arising from dorsal or ventral pancreas.Between January 2014 and February 2018, 101 patients with resectable pancreatic head cancer who underwent pancreaticoduodenectomy in our institution were retrospectively reviewed. The patients were assigned into 2 groups according to tumor location on preoperative imaging materials (computed tomography/magnetic resonance imaging [CT/MRI]), and the clinicopathological features and prognosis were retrospectively analyzed in view of the embryonic development of the pancreas.Among these patients with pancreatic head cancer, 42 patients had tumors arising from dorsal pancreas (D group) and 59 patients had tumors arising from ventral pancreas (V group). The frequency of lymph node (LN) metastasis around the common hepatic artery (CHA) and hepatoduodenal ligament lymph nodes in the D group was higher than that in the V group (45.2% vs 10.2%, P = .001). And the rate of LN metastasis in the superior mesenteric artery (SMA) region in the V group is higher than that in the D group (32.2% vs 4.8%, P = .002). The D group was more likely to invade the common bile duct (78.6% vs 59.3%, P = .042) and duodenum (71.4% vs 44.1%, P = .006) than the V group. In addition, the survival outcome of V group was better than D group (median overall survival [OS], 15.37 months vs 10.53 months, P = .048, median DFS 9.73 months vs 5.93 months, P = .046).The clinicopathological features of pancreatic head carcinoma arising from dorsal or ventral pancreas are different, and the pancreatic head carcinoma arising from ventral pancreas has a better survival outcome. |
| doi_str_mv | 10.1097/MD.0000000000026167 |
| format | Article |
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This study aims to explore whether there are differences in clinicopathological features and prognosis of pancreatic head carcinoma arising from dorsal or ventral pancreas.Between January 2014 and February 2018, 101 patients with resectable pancreatic head cancer who underwent pancreaticoduodenectomy in our institution were retrospectively reviewed. The patients were assigned into 2 groups according to tumor location on preoperative imaging materials (computed tomography/magnetic resonance imaging [CT/MRI]), and the clinicopathological features and prognosis were retrospectively analyzed in view of the embryonic development of the pancreas.Among these patients with pancreatic head cancer, 42 patients had tumors arising from dorsal pancreas (D group) and 59 patients had tumors arising from ventral pancreas (V group). The frequency of lymph node (LN) metastasis around the common hepatic artery (CHA) and hepatoduodenal ligament lymph nodes in the D group was higher than that in the V group (45.2% vs 10.2%, P = .001). And the rate of LN metastasis in the superior mesenteric artery (SMA) region in the V group is higher than that in the D group (32.2% vs 4.8%, P = .002). The D group was more likely to invade the common bile duct (78.6% vs 59.3%, P = .042) and duodenum (71.4% vs 44.1%, P = .006) than the V group. In addition, the survival outcome of V group was better than D group (median overall survival [OS], 15.37 months vs 10.53 months, P = .048, median DFS 9.73 months vs 5.93 months, P = .046).The clinicopathological features of pancreatic head carcinoma arising from dorsal or ventral pancreas are different, and the pancreatic head carcinoma arising from ventral pancreas has a better survival outcome.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000026167</identifier><identifier>PMID: 34087876</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Comorbidity ; Female ; Health Behavior ; Humans ; Lymphatic Metastasis - pathology ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Observational Study ; Pancreatic Neoplasms ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology</subject><ispartof>Medicine (Baltimore), 2021-06, Vol.100 (22), p.e26167-e26167</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3559-6cc9244aadf1de540e9e308b2f15da5fb60448d4de1ee807dce053da6c91150c3</cites><orcidid>0000-0003-2336-1805 ; 0000-0001-7080-1442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183761/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183761/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34087876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Dasong</creatorcontrib><creatorcontrib>Zeng, Qihui</creatorcontrib><creatorcontrib>Niu, Xiaoya</creatorcontrib><creatorcontrib>Chen, Xinghan</creatorcontrib><creatorcontrib>Ye, Hui</creatorcontrib><title>Differences in the clinicopathological features of pancreatic head carcinoma in dorsal and ventral pancreas: A single institution retrospective review</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The embryonic development of the pancreas originates from dorsal and ventral anlagen, and the pancreatic cancer arising from dorsal or ventral pancreas may have different clinical pathology features. This study aims to explore whether there are differences in clinicopathological features and prognosis of pancreatic head carcinoma arising from dorsal or ventral pancreas.Between January 2014 and February 2018, 101 patients with resectable pancreatic head cancer who underwent pancreaticoduodenectomy in our institution were retrospectively reviewed. The patients were assigned into 2 groups according to tumor location on preoperative imaging materials (computed tomography/magnetic resonance imaging [CT/MRI]), and the clinicopathological features and prognosis were retrospectively analyzed in view of the embryonic development of the pancreas.Among these patients with pancreatic head cancer, 42 patients had tumors arising from dorsal pancreas (D group) and 59 patients had tumors arising from ventral pancreas (V group). The frequency of lymph node (LN) metastasis around the common hepatic artery (CHA) and hepatoduodenal ligament lymph nodes in the D group was higher than that in the V group (45.2% vs 10.2%, P = .001). And the rate of LN metastasis in the superior mesenteric artery (SMA) region in the V group is higher than that in the D group (32.2% vs 4.8%, P = .002). The D group was more likely to invade the common bile duct (78.6% vs 59.3%, P = .042) and duodenum (71.4% vs 44.1%, P = .006) than the V group. In addition, the survival outcome of V group was better than D group (median overall survival [OS], 15.37 months vs 10.53 months, P = .048, median DFS 9.73 months vs 5.93 months, P = .046).The clinicopathological features of pancreatic head carcinoma arising from dorsal or ventral pancreas are different, and the pancreatic head carcinoma arising from ventral pancreas has a better survival outcome.</description><subject>Adult</subject><subject>Aged</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Health Behavior</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Observational Study</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc-OFCEQxjtG446rT2BiOHrpFRpoGg8mmx11TXbjRc-EgepplIER6Jn4Ivu8Mjvj-ocLVNWvPgq-pnlJ8AXBUry5XV7gP6vrSS8eNQvCad9y2bPHzaJmeSukYGfNs5y_YUyo6NjT5owyPIhB9IvmbunGERIEAxm5gMoEyHgXnIlbXabo49oZ7dEIusypMnFEWx1MqrEzaAJtkdHJuBA3-iBgY8qV18GiHYSS6vnE57foEmUX1h4qmIsrc3ExoAQlxbwFU9wOarRzsH_ePBm1z_DitJ83Xz-8_3J13d58_vjp6vKmNZRz2fbGyI4xre1ILHCGQQLFw6obCbeaj6seMzZYZoEADFhYA5hTq3sjCeHY0PPm3VF3O682UMv3E6ttchudfqqonfq3Etyk1nGnBjJQ0ZMq8PokkOKPGXJRG5cNeK8DxDmrjleMYcl4RekRNfW5OcH4cA3B6uCoul2q_x2tXa_-nvCh57eFFWBHYB99gZS_-3kPSVVnfJnu9biQXdvhjuD6Hbg9ZCT9BSU0sQI</recordid><startdate>20210604</startdate><enddate>20210604</enddate><creator>Wang, Dasong</creator><creator>Zeng, Qihui</creator><creator>Niu, Xiaoya</creator><creator>Chen, Xinghan</creator><creator>Ye, Hui</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2336-1805</orcidid><orcidid>https://orcid.org/0000-0001-7080-1442</orcidid></search><sort><creationdate>20210604</creationdate><title>Differences in the clinicopathological features of pancreatic head carcinoma in dorsal and ventral pancreas: A single institution retrospective review</title><author>Wang, Dasong ; Zeng, Qihui ; Niu, Xiaoya ; Chen, Xinghan ; Ye, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3559-6cc9244aadf1de540e9e308b2f15da5fb60448d4de1ee807dce053da6c91150c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Health Behavior</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Observational Study</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreatic Neoplasms - diagnostic imaging</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Dasong</creatorcontrib><creatorcontrib>Zeng, Qihui</creatorcontrib><creatorcontrib>Niu, Xiaoya</creatorcontrib><creatorcontrib>Chen, Xinghan</creatorcontrib><creatorcontrib>Ye, Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Dasong</au><au>Zeng, Qihui</au><au>Niu, Xiaoya</au><au>Chen, Xinghan</au><au>Ye, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in the clinicopathological features of pancreatic head carcinoma in dorsal and ventral pancreas: A single institution retrospective review</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-06-04</date><risdate>2021</risdate><volume>100</volume><issue>22</issue><spage>e26167</spage><epage>e26167</epage><pages>e26167-e26167</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The embryonic development of the pancreas originates from dorsal and ventral anlagen, and the pancreatic cancer arising from dorsal or ventral pancreas may have different clinical pathology features. This study aims to explore whether there are differences in clinicopathological features and prognosis of pancreatic head carcinoma arising from dorsal or ventral pancreas.Between January 2014 and February 2018, 101 patients with resectable pancreatic head cancer who underwent pancreaticoduodenectomy in our institution were retrospectively reviewed. The patients were assigned into 2 groups according to tumor location on preoperative imaging materials (computed tomography/magnetic resonance imaging [CT/MRI]), and the clinicopathological features and prognosis were retrospectively analyzed in view of the embryonic development of the pancreas.Among these patients with pancreatic head cancer, 42 patients had tumors arising from dorsal pancreas (D group) and 59 patients had tumors arising from ventral pancreas (V group). The frequency of lymph node (LN) metastasis around the common hepatic artery (CHA) and hepatoduodenal ligament lymph nodes in the D group was higher than that in the V group (45.2% vs 10.2%, P = .001). And the rate of LN metastasis in the superior mesenteric artery (SMA) region in the V group is higher than that in the D group (32.2% vs 4.8%, P = .002). The D group was more likely to invade the common bile duct (78.6% vs 59.3%, P = .042) and duodenum (71.4% vs 44.1%, P = .006) than the V group. In addition, the survival outcome of V group was better than D group (median overall survival [OS], 15.37 months vs 10.53 months, P = .048, median DFS 9.73 months vs 5.93 months, P = .046).The clinicopathological features of pancreatic head carcinoma arising from dorsal or ventral pancreas are different, and the pancreatic head carcinoma arising from ventral pancreas has a better survival outcome.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34087876</pmid><doi>10.1097/MD.0000000000026167</doi><orcidid>https://orcid.org/0000-0003-2336-1805</orcidid><orcidid>https://orcid.org/0000-0001-7080-1442</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Comorbidity Female Health Behavior Humans Lymphatic Metastasis - pathology Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Observational Study Pancreatic Neoplasms Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology |
| title | Differences in the clinicopathological features of pancreatic head carcinoma in dorsal and ventral pancreas: A single institution retrospective review |
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