Piperazine skeleton in the structural modification of natural products: a review
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over 100 molecules with a broad range of bioactivi...
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2021-01, Vol.36 (1), p.1165-1197 |
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| container_end_page | 1197 |
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| container_issue | 1 |
| container_start_page | 1165 |
| container_title | Journal of enzyme inhibition and medicinal chemistry |
| container_volume | 36 |
| creator | Zhang, Run-Hui Guo, Hong-Yan Deng, Hao Li, Jinzi Quan, Zhe-Shan |
| description | Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over 100 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antioxidant, and other activities, were reviewed. This article reviewed investigations regarding piperazine groups for the modification of natural product derivatives in the last decade, highlighting parameters that affect their biological activity. |
| doi_str_mv | 10.1080/14756366.2021.1931861 |
| format | Article |
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| identifier | ISSN: 1475-6366 |
| ispartof | Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.1165-1197 |
| issn | 1475-6366 1475-6374 |
| language | eng |
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| source | Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | natural product pharmacological activity Piperazine Review structure-activity relationship |
| title | Piperazine skeleton in the structural modification of natural products: a review |
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