Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Interferons can diminish HBV cccDNA via APOBEC3-mediated deamination. Here, we show that overexpression of APOBEC3A alone is not...

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Veröffentlicht in:	EMBO reports 2021-06, Vol.22 (6), p.e49568-n/a
Hauptverfasser:	Stadler, Daniela, Kächele, Martin, Jones, Alisha N, Hess, Julia, Urban, Christian, Schneider, Jessica, Xia, Yuchen, Oswald, Andreas, Nebioglu, Firat, Bester, Romina, Lasitschka, Felix, Ringelhan, Marc, Ko, Chunkyu, Chou, Wen-Min, Geerlof, Arie, van de Klundert, Maarten A, Wettengel, Jochen M, Schirmacher, Peter, Heikenwälder, Mathias, Schreiner, Sabrina, Bartenschlager, Ralf, Pichlmair, Andreas, Sattler, Michael, Unger, Kristian, Protzer, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral activity Antiviral agents Antiviral Agents - pharmacology APOBEC3A chronic hepatitis B Circular DNA Cytidine Deaminase Deamination Degradation Deoxyribonucleic acid Depletion DNA DNA, Circular - genetics DNA, Viral - genetics DNA, Viral - pharmacology EMBO19 EMBO23 Exoribonucleases Gene expression HBV Hepatitis Hepatitis B Hepatitis B virus - genetics Hepatocytes Humans Interferon interferon alpha interferon gamma Interferons Nuclease Nuclei (cytology) Nucleoli Proteins Purging Therapeutic targets Transcription Transcriptomes Virus Replication Viruses
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