Examination of the effects of COVID 19 on corneal endothelium
Purpose To demonstrate the effects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy. Methods Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining v...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2021-08, Vol.259 (8), p.2295-2300 |
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| creator | Erdem, Seyfettin Karahan, Mine Ava, Sedat Dursun, Mehmet Emin Hazar, Leyla Keklikci, Ugur |
| description | Purpose
To demonstrate the effects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy.
Methods
Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining visual acuity, refractive defect detection, anterior and posterior segment examinations, and specular microscopy measurements were calculated from images with at least 100 cells. The mean cell density (CD), mean coefficient of variation (CV), mean hexagonal cell percentage, mean cell area (AVG), and central corneal thickness (CCT) were evaluated.
Results
The mean time from diagnosis of the disease in group 1 was 54.25 ± 6.36 days. The mean time elapsed since the PCR test became negative was 38.45 ± 6.87 days. Only four were treated in the hospital. Specular microscopy data showed that the CD was 2713.56 ± 246.25 and 2845.80 ± 299.27 in groups 1 and 2, respectively (
p
= 0.003). The CV values were 42.92 ± 6.79 and 40.16 ± 5.97, respectively (
p
= 0.009). The hexagonality were 46.51 ± 7.35 and 49.12 ± 6.87, respectively (
p
= 0.024). The AVG was 371.60 ± 34.64 and 353.16 ± 35.29, respectively (
p
= 0.007). The CCT values were 553.00 ± 73.2, and 526.84 ± 33.57, respectively (
p
= 0.005).
Conclusion
A decrease in the number of endothelial cells and hexagonal cells (polymorphism) as well as an increase in the cell area change coefficient (polymegatism) and the average cell area were observed from corneal specular microscopic examination of individuals recovering from COVID-19 in the early period of the disease. These results may be important in understanding the systemic effects of the disease. |
| doi_str_mv | 10.1007/s00417-021-05259-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8181541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2559539988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-247b9f87690bc948591fbac01f2d9dc2491baf187bf189eba273be1d79dcbebb3</originalsourceid><addsrcrecordid>eNp9kcFOHSEUhklTo1frC3Q1STfdjJ4DQ4FFmzS3Vk1M3NjGHQEGdMwMWJgx9e3L7TVtdOEGQv7vfDnkJ-Q9whECiOMC0KFogWILnHLVwhuywo7xVgC9fktWIGokGb3eI_ul3EHlGcddssc6UAIRV-TzyW8zDdHMQ4pNCs186xsfgndz2TzXlz_PvzWompq6lKM3Y-Njnyo2Dsv0juwEMxZ_-HQfkB_fT67WZ-3F5en5-utF6zqOc0s7YVWQ4pMC61QnucJgjQMMtFe9o51CawJKYeuhvDVUMOuxFzW03lp2QL5svfeLnXzvfJyzGfV9HiaTH3Uyg36exOFW36QHLVEi77AKPj4Jcvq1-DLraSjOj6OJPi1FU84kcEAOFf3wAr1LS471e5XiijOlpKwU3VIup1KyD_-WQdCbdvS2HV3b0X_b0Rs12w6VCscbn_-rX5n6A2u5kFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559539988</pqid></control><display><type>article</type><title>Examination of the effects of COVID 19 on corneal endothelium</title><source>SpringerLink Journals - AutoHoldings</source><creator>Erdem, Seyfettin ; Karahan, Mine ; Ava, Sedat ; Dursun, Mehmet Emin ; Hazar, Leyla ; Keklikci, Ugur</creator><creatorcontrib>Erdem, Seyfettin ; Karahan, Mine ; Ava, Sedat ; Dursun, Mehmet Emin ; Hazar, Leyla ; Keklikci, Ugur</creatorcontrib><description>Purpose
To demonstrate the effects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy.
Methods
Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining visual acuity, refractive defect detection, anterior and posterior segment examinations, and specular microscopy measurements were calculated from images with at least 100 cells. The mean cell density (CD), mean coefficient of variation (CV), mean hexagonal cell percentage, mean cell area (AVG), and central corneal thickness (CCT) were evaluated.
Results
The mean time from diagnosis of the disease in group 1 was 54.25 ± 6.36 days. The mean time elapsed since the PCR test became negative was 38.45 ± 6.87 days. Only four were treated in the hospital. Specular microscopy data showed that the CD was 2713.56 ± 246.25 and 2845.80 ± 299.27 in groups 1 and 2, respectively (
p
= 0.003). The CV values were 42.92 ± 6.79 and 40.16 ± 5.97, respectively (
p
= 0.009). The hexagonality were 46.51 ± 7.35 and 49.12 ± 6.87, respectively (
p
= 0.024). The AVG was 371.60 ± 34.64 and 353.16 ± 35.29, respectively (
p
= 0.007). The CCT values were 553.00 ± 73.2, and 526.84 ± 33.57, respectively (
p
= 0.005).
Conclusion
A decrease in the number of endothelial cells and hexagonal cells (polymorphism) as well as an increase in the cell area change coefficient (polymegatism) and the average cell area were observed from corneal specular microscopic examination of individuals recovering from COVID-19 in the early period of the disease. These results may be important in understanding the systemic effects of the disease.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-021-05259-0</identifier><identifier>PMID: 34097111</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acuity ; Cell density ; Cornea ; Coronaviruses ; COVID-19 ; Endothelial cells ; Endothelium ; Eye diseases ; Medicine ; Medicine & Public Health ; Microscopy ; Ophthalmology ; Perspectives on COVID-19</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2021-08, Vol.259 (8), p.2295-2300</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-247b9f87690bc948591fbac01f2d9dc2491baf187bf189eba273be1d79dcbebb3</citedby><cites>FETCH-LOGICAL-c451t-247b9f87690bc948591fbac01f2d9dc2491baf187bf189eba273be1d79dcbebb3</cites><orcidid>0000-0001-5742-1293</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-021-05259-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-021-05259-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27922,27923,41486,42555,51317</link.rule.ids></links><search><creatorcontrib>Erdem, Seyfettin</creatorcontrib><creatorcontrib>Karahan, Mine</creatorcontrib><creatorcontrib>Ava, Sedat</creatorcontrib><creatorcontrib>Dursun, Mehmet Emin</creatorcontrib><creatorcontrib>Hazar, Leyla</creatorcontrib><creatorcontrib>Keklikci, Ugur</creatorcontrib><title>Examination of the effects of COVID 19 on corneal endothelium</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To demonstrate the effects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy.
Methods
Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining visual acuity, refractive defect detection, anterior and posterior segment examinations, and specular microscopy measurements were calculated from images with at least 100 cells. The mean cell density (CD), mean coefficient of variation (CV), mean hexagonal cell percentage, mean cell area (AVG), and central corneal thickness (CCT) were evaluated.
Results
The mean time from diagnosis of the disease in group 1 was 54.25 ± 6.36 days. The mean time elapsed since the PCR test became negative was 38.45 ± 6.87 days. Only four were treated in the hospital. Specular microscopy data showed that the CD was 2713.56 ± 246.25 and 2845.80 ± 299.27 in groups 1 and 2, respectively (
p
= 0.003). The CV values were 42.92 ± 6.79 and 40.16 ± 5.97, respectively (
p
= 0.009). The hexagonality were 46.51 ± 7.35 and 49.12 ± 6.87, respectively (
p
= 0.024). The AVG was 371.60 ± 34.64 and 353.16 ± 35.29, respectively (
p
= 0.007). The CCT values were 553.00 ± 73.2, and 526.84 ± 33.57, respectively (
p
= 0.005).
Conclusion
A decrease in the number of endothelial cells and hexagonal cells (polymorphism) as well as an increase in the cell area change coefficient (polymegatism) and the average cell area were observed from corneal specular microscopic examination of individuals recovering from COVID-19 in the early period of the disease. These results may be important in understanding the systemic effects of the disease.</description><subject>Acuity</subject><subject>Cell density</subject><subject>Cornea</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Eye diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy</subject><subject>Ophthalmology</subject><subject>Perspectives on COVID-19</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcFOHSEUhklTo1frC3Q1STfdjJ4DQ4FFmzS3Vk1M3NjGHQEGdMwMWJgx9e3L7TVtdOEGQv7vfDnkJ-Q9whECiOMC0KFogWILnHLVwhuywo7xVgC9fktWIGokGb3eI_ul3EHlGcddssc6UAIRV-TzyW8zDdHMQ4pNCs186xsfgndz2TzXlz_PvzWompq6lKM3Y-Njnyo2Dsv0juwEMxZ_-HQfkB_fT67WZ-3F5en5-utF6zqOc0s7YVWQ4pMC61QnucJgjQMMtFe9o51CawJKYeuhvDVUMOuxFzW03lp2QL5svfeLnXzvfJyzGfV9HiaTH3Uyg36exOFW36QHLVEi77AKPj4Jcvq1-DLraSjOj6OJPi1FU84kcEAOFf3wAr1LS471e5XiijOlpKwU3VIup1KyD_-WQdCbdvS2HV3b0X_b0Rs12w6VCscbn_-rX5n6A2u5kFQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Erdem, Seyfettin</creator><creator>Karahan, Mine</creator><creator>Ava, Sedat</creator><creator>Dursun, Mehmet Emin</creator><creator>Hazar, Leyla</creator><creator>Keklikci, Ugur</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5742-1293</orcidid></search><sort><creationdate>20210801</creationdate><title>Examination of the effects of COVID 19 on corneal endothelium</title><author>Erdem, Seyfettin ; Karahan, Mine ; Ava, Sedat ; Dursun, Mehmet Emin ; Hazar, Leyla ; Keklikci, Ugur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-247b9f87690bc948591fbac01f2d9dc2491baf187bf189eba273be1d79dcbebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acuity</topic><topic>Cell density</topic><topic>Cornea</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Eye diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy</topic><topic>Ophthalmology</topic><topic>Perspectives on COVID-19</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdem, Seyfettin</creatorcontrib><creatorcontrib>Karahan, Mine</creatorcontrib><creatorcontrib>Ava, Sedat</creatorcontrib><creatorcontrib>Dursun, Mehmet Emin</creatorcontrib><creatorcontrib>Hazar, Leyla</creatorcontrib><creatorcontrib>Keklikci, Ugur</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdem, Seyfettin</au><au>Karahan, Mine</au><au>Ava, Sedat</au><au>Dursun, Mehmet Emin</au><au>Hazar, Leyla</au><au>Keklikci, Ugur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of the effects of COVID 19 on corneal endothelium</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>259</volume><issue>8</issue><spage>2295</spage><epage>2300</epage><pages>2295-2300</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To demonstrate the effects of the disease on the corneal endothelium in individuals recovering from COVID-19 through specular microscopy.
Methods
Eighty individuals recovering from COVID-19 (group 1) and 72 healthy controls (group 2) were included in this prospective study. After examining visual acuity, refractive defect detection, anterior and posterior segment examinations, and specular microscopy measurements were calculated from images with at least 100 cells. The mean cell density (CD), mean coefficient of variation (CV), mean hexagonal cell percentage, mean cell area (AVG), and central corneal thickness (CCT) were evaluated.
Results
The mean time from diagnosis of the disease in group 1 was 54.25 ± 6.36 days. The mean time elapsed since the PCR test became negative was 38.45 ± 6.87 days. Only four were treated in the hospital. Specular microscopy data showed that the CD was 2713.56 ± 246.25 and 2845.80 ± 299.27 in groups 1 and 2, respectively (
p
= 0.003). The CV values were 42.92 ± 6.79 and 40.16 ± 5.97, respectively (
p
= 0.009). The hexagonality were 46.51 ± 7.35 and 49.12 ± 6.87, respectively (
p
= 0.024). The AVG was 371.60 ± 34.64 and 353.16 ± 35.29, respectively (
p
= 0.007). The CCT values were 553.00 ± 73.2, and 526.84 ± 33.57, respectively (
p
= 0.005).
Conclusion
A decrease in the number of endothelial cells and hexagonal cells (polymorphism) as well as an increase in the cell area change coefficient (polymegatism) and the average cell area were observed from corneal specular microscopic examination of individuals recovering from COVID-19 in the early period of the disease. These results may be important in understanding the systemic effects of the disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34097111</pmid><doi>10.1007/s00417-021-05259-0</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5742-1293</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2021-08, Vol.259 (8), p.2295-2300 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8181541 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Acuity Cell density Cornea Coronaviruses COVID-19 Endothelial cells Endothelium Eye diseases Medicine Medicine & Public Health Microscopy Ophthalmology Perspectives on COVID-19 |
| title | Examination of the effects of COVID 19 on corneal endothelium |
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