Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice

Background. ML171 is a potent nicotinamide adenine dinucleotide phosphate oxidase (NOX) inhibitor with isoform selectivity only for NOX1. This study is aimed at investigating the safety of ML171 after a single intraperitoneal (IP) injection in mice. Methods. The toxicity of a single dose of ML171 wa...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.5515478-5515478
Hauptverfasser:	Oh, Se-Hyun, Ahn, Ji-Sun, Oh, Eun-Joo, Kim, You-Jin, Yook, Ju-Min, Lim, Jeong-Hoon, Jung, Hee-Yeon, Choi, Ji-Young, Kim, Chan-Duck, Park, Sun-Hee, Kim, Yong-Lim, Cho, Jang-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acclimatization Adenine Animals Autopsies Cancer research Clinical trials Drug dosages Drug Evaluation, Preclinical Enzyme inhibitors Evaluation Experiments FDA approval Female Females Hepatocytes Histopathology Hypertension Hypertrophy Inflammation Inhibitors Injection Kinases Laboratories Liver Male Males Mice Mice, Inbred ICR Mortality NAD(P)H oxidase NADPH Oxidase 1 - antagonists & inhibitors NADPH-diaphorase Nicotinamide Nicotinamide adenine dinucleotide Organs Oxidases Oxidative stress Phenothiazines - pharmacology Phenothiazines - toxicity Physiological aspects Physiology Protein Isoforms Safety Selectivity Statistical analysis Toxicity Toxicity Tests Variance analysis
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