Comparative Analysis and in vitro Experiments of Signatures and Prognostic Value of Immune Checkpoint Genes in Colorectal Cancer

Immune checkpoints, as pivotal regulators of immune escape in cancer, can motivate the emergence of immune checkpoint inhibitors (ICIs). The aim of this study is to identify the expression of the immune checkpoint genes (ICGs) in colorectal cancer (CRC) and to relate their individual as well as comb...

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Veröffentlicht in:	OncoTargets and therapy 2021-01, Vol.14, p.3517-3534
Hauptverfasser:	Ma, Rui, Qu, Xiujuan, Che, Xiaofang, Yang, Bowen, Li, Ce, Hou, Kezuo, Guo, Tianshu, Xiao, Jiawen, Liu, Yunpeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Biomarkers Cancer Cancer therapies Colorectal cancer Colorectal carcinoma Comparative analysis Cytotoxicity Datasets Flow cytometry Gene expression Genes Genetic aspects Genomes Health aspects Immune checkpoint Immune checkpoint inhibitors Immune system Immunotherapy Information retrieval Medical prognosis Mutation Natural killer cells Neoantigens Original Research PD-1 protein PD-L1 protein Prognosis RNA Tumor cells
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