Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental physiological functions via four G protein-coupled receptors, V 1a R, V 1b R, V 2 R, and OTR. Ligand development remains challenging for these receptors due to complex structure-activity relationships. Here, we inv...

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Veröffentlicht in:	Chemical science (Cambridge) 2021-03, Vol.12 (11), p.457-462
Hauptverfasser:	Dekan, Zoltan, Kremsmayr, Thomas, Keov, Peter, Godin, Mathilde, Teakle, Ngari, Dürrauer, Leopold, Xiang, Huang, Gharib, Dalia, Bergmayr, Christian, Hellinger, Roland, Gay, Marina, Vilaseca, Marta, Kurzbach, Dennis, Albericio, Fernando, Alewood, Paul F, Gruber, Christian W, Muttenthaler, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Construction Dimerization Dimers Ligands Mass spectra Pharmacology Receptors Structural analysis Valine
Online-Zugang:	Volltext
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