Targeting the APP-Mint2 Protein–Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid‑β Formation

There is an urgent need for novel therapeutic approaches to treat Alzheimer’s disease (AD) with the ability to both alleviate the clinical symptoms and halt the progression of the disease. AD is characterized by the accumulation of amyloid-β (Aβ) peptides which are generated through the sequential p...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-01, Vol.143 (2), p.891-901
Hauptverfasser:	Bartling, Christian R. O, Jensen, Thomas M. T, Henry, Shawna M, Colliander, Anna L, Sereikaite, Vita, Wenzler, Marcella, Jain, Palash, Maric, Hans M, Harpsøe, Kasper, Pedersen, Søren W, Clemmensen, Louise S, Haugaard-Kedström, Linda M, Gloriam, David E, Ho, Angela, Strømgaard, Kristian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - antagonists & inhibitors Amyloid beta-Protein Precursor - metabolism Cadherins - antagonists & inhibitors Cadherins - metabolism Humans Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Protein Binding - drug effects
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