No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh
Successful achievement of global targets for elimination of trachoma as a public health problem and eradication of yaws will require control efforts to reach marginalized populations, including refugees. Testing for serologic evidence of transmission of trachoma and yaws in residents of registered c...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2021-06, Vol.104 (6), p.2031-2037 |
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| creator | Cooley, Gretchen M Feldstein, Leora R Bennett, Sarah D Estivariz, Concepcion F Weil, Lauren Bohara, Rajendra Vandenent, Maya Mainul Hasan, Asm Akhtar, Mohammad Saifuddin Uzzaman, M Salim Billah, Mallick Masum Conklin, Laura Ehlman, Daniel C Asiedu, Kingsley Solomon, Anthony W Alamgir, Asm Flora, Meerjady Sabrina Martin, Diana L |
| description | Successful achievement of global targets for elimination of trachoma as a public health problem and eradication of yaws will require control efforts to reach marginalized populations, including refugees. Testing for serologic evidence of transmission of trachoma and yaws in residents of registered camps and a Makeshift Settlement in Cox's Bazar District, Bangladesh, was added to a serosurvey for vaccine-preventable diseases (VPDs) conducted April-May 2018. The survey was primarily designed to estimate remaining immunity gaps for VPDs, including diphtheria, measles, rubella, and polio. Blood specimens from 1- to 14-year-olds from selected households were collected and tested for antibody responses against antigens from Treponema pallidum and Chlamydia trachomatis using a multiplex bead assay to evaluate for serologic evidence of the neglected tropical diseases (NTDs) yaws and trachoma, respectively. The prevalence of antibodies against two C. trachomatis antigens in children ranged from 1.4% to 1.5% for Pgp3 and 2.8% to 7.0% for CT694. The prevalence of antibody responses against both of two treponemal antigens (recombinant protein17 and treponemal membrane protein A) tested was 0% to 0.15% in two camps. The data are suggestive of very low or no transmission of trachoma and yaws, currently or previously, in children resident in these communities. This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources. |
| doi_str_mv | 10.4269/ajtmh.21-0124 |
| format | Article |
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Testing for serologic evidence of transmission of trachoma and yaws in residents of registered camps and a Makeshift Settlement in Cox's Bazar District, Bangladesh, was added to a serosurvey for vaccine-preventable diseases (VPDs) conducted April-May 2018. The survey was primarily designed to estimate remaining immunity gaps for VPDs, including diphtheria, measles, rubella, and polio. Blood specimens from 1- to 14-year-olds from selected households were collected and tested for antibody responses against antigens from Treponema pallidum and Chlamydia trachomatis using a multiplex bead assay to evaluate for serologic evidence of the neglected tropical diseases (NTDs) yaws and trachoma, respectively. The prevalence of antibodies against two C. trachomatis antigens in children ranged from 1.4% to 1.5% for Pgp3 and 2.8% to 7.0% for CT694. The prevalence of antibody responses against both of two treponemal antigens (recombinant protein17 and treponemal membrane protein A) tested was 0% to 0.15% in two camps. The data are suggestive of very low or no transmission of trachoma and yaws, currently or previously, in children resident in these communities. This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.21-0124</identifier><identifier>PMID: 33939630</identifier><language>eng</language><publisher>United States: Institute of Tropical Medicine</publisher><subject>Adolescent ; Antibodies, Bacterial - blood ; Antigens ; Bangladesh - epidemiology ; Child ; Child, Preschool ; Chlamydia trachomatis - immunology ; Female ; Humans ; Infant ; Male ; Prevalence ; Public Health ; Refugees - statistics & numerical data ; Seroepidemiologic Studies ; Serologic Tests - statistics & numerical data ; Trachoma - blood ; Trachoma - epidemiology ; Trachoma - immunology ; Treponema pallidum - immunology ; Yaws - blood ; Yaws - epidemiology ; Yaws - immunology</subject><ispartof>The American journal of tropical medicine and hygiene, 2021-06, Vol.104 (6), p.2031-2037</ispartof><rights>Copyright Institute of Tropical Medicine Jun 2021</rights><rights>2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-cbd26429a0589cda12384e3522a17866fa6f176cf54ab270e4fdea6508e93ff83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176462/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176462/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33939630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooley, Gretchen M</creatorcontrib><creatorcontrib>Feldstein, Leora R</creatorcontrib><creatorcontrib>Bennett, Sarah D</creatorcontrib><creatorcontrib>Estivariz, Concepcion F</creatorcontrib><creatorcontrib>Weil, Lauren</creatorcontrib><creatorcontrib>Bohara, Rajendra</creatorcontrib><creatorcontrib>Vandenent, Maya</creatorcontrib><creatorcontrib>Mainul Hasan, Asm</creatorcontrib><creatorcontrib>Akhtar, Mohammad Saifuddin</creatorcontrib><creatorcontrib>Uzzaman, M Salim</creatorcontrib><creatorcontrib>Billah, Mallick Masum</creatorcontrib><creatorcontrib>Conklin, Laura</creatorcontrib><creatorcontrib>Ehlman, Daniel C</creatorcontrib><creatorcontrib>Asiedu, Kingsley</creatorcontrib><creatorcontrib>Solomon, Anthony W</creatorcontrib><creatorcontrib>Alamgir, Asm</creatorcontrib><creatorcontrib>Flora, Meerjady Sabrina</creatorcontrib><creatorcontrib>Martin, Diana L</creatorcontrib><title>No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Successful achievement of global targets for elimination of trachoma as a public health problem and eradication of yaws will require control efforts to reach marginalized populations, including refugees. 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Testing for serologic evidence of transmission of trachoma and yaws in residents of registered camps and a Makeshift Settlement in Cox's Bazar District, Bangladesh, was added to a serosurvey for vaccine-preventable diseases (VPDs) conducted April-May 2018. The survey was primarily designed to estimate remaining immunity gaps for VPDs, including diphtheria, measles, rubella, and polio. Blood specimens from 1- to 14-year-olds from selected households were collected and tested for antibody responses against antigens from Treponema pallidum and Chlamydia trachomatis using a multiplex bead assay to evaluate for serologic evidence of the neglected tropical diseases (NTDs) yaws and trachoma, respectively. The prevalence of antibodies against two C. trachomatis antigens in children ranged from 1.4% to 1.5% for Pgp3 and 2.8% to 7.0% for CT694. The prevalence of antibody responses against both of two treponemal antigens (recombinant protein17 and treponemal membrane protein A) tested was 0% to 0.15% in two camps. The data are suggestive of very low or no transmission of trachoma and yaws, currently or previously, in children resident in these communities. This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.</abstract><cop>United States</cop><pub>Institute of Tropical Medicine</pub><pmid>33939630</pmid><doi>10.4269/ajtmh.21-0124</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Antibodies, Bacterial - blood Antigens Bangladesh - epidemiology Child Child, Preschool Chlamydia trachomatis - immunology Female Humans Infant Male Prevalence Public Health Refugees - statistics & numerical data Seroepidemiologic Studies Serologic Tests - statistics & numerical data Trachoma - blood Trachoma - epidemiology Trachoma - immunology Treponema pallidum - immunology Yaws - blood Yaws - epidemiology Yaws - immunology |
| title | No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh |
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