Assessment of Blood Flow Velocity and Diameter of the Middle Cerebral Artery during the Acetazolamide Provocation Test by Use of Transcranial Doppler Sonography and MR Imaging
Our purpose was to show changes in the diameter of the M1 segment of the middle cerebral artery (MCA) by using high-resolution MR imaging in patients with chronic internal carotid artery occlusion after IV administered acetazolamide challenge. Changes in blood flow velocity of the basal cerebral art...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2000-08, Vol.21 (7), p.1207-1211 |
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| creator | Schreiber, Stephan J Gottschalk, Stefan Weih, Markus Villringer, Arno Valdueza, Jose M |
| description | Our purpose was to show changes in the diameter of the M1 segment of the middle cerebral artery (MCA) by using high-resolution MR imaging in patients with chronic internal carotid artery occlusion after IV administered acetazolamide challenge. Changes in blood flow velocity of the basal cerebral arteries are thought to correlate with changes of cerebral blood flow. Changes in the diameter of the basal cerebral arteries, however, might influence the validity of transcranial Doppler measurements.
Eight patients with internal carotid artery occlusion who were undergoing acetazolamide testing for assessment of cerebrovascular vasomotor reactivity were included in the study. Blood flow velocities of both MCAs were measured with transcranial Doppler sonography before and 25 minutes after the administration of acetazolamide. Before and 15 minutes after the administration of medication, MR imaging was performed contralateral to the occlusion side. A T2-weighted turbo-gradient spin-echo sequence was chosen to show a cross section of the M1 segment in high resolution (pixels, 0.27 x 0.29 mm). Based on interpolated data, the smallest and greatest MCA diameters were determined.
We did not find changes in the diameter of the MCA after acetazolamide provocation testing with high-resolution MR imaging in patients with occlusive extracranial carotid artery disease.
The results of our study support the hypothesis that changes in MCA flow velocity measured by transcranial Doppler sonography reflect relative changes in cerebral blood flow after acetazolamide provocation testing. |
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Eight patients with internal carotid artery occlusion who were undergoing acetazolamide testing for assessment of cerebrovascular vasomotor reactivity were included in the study. Blood flow velocities of both MCAs were measured with transcranial Doppler sonography before and 25 minutes after the administration of acetazolamide. Before and 15 minutes after the administration of medication, MR imaging was performed contralateral to the occlusion side. A T2-weighted turbo-gradient spin-echo sequence was chosen to show a cross section of the M1 segment in high resolution (pixels, 0.27 x 0.29 mm). Based on interpolated data, the smallest and greatest MCA diameters were determined.
We did not find changes in the diameter of the MCA after acetazolamide provocation testing with high-resolution MR imaging in patients with occlusive extracranial carotid artery disease.
The results of our study support the hypothesis that changes in MCA flow velocity measured by transcranial Doppler sonography reflect relative changes in cerebral blood flow after acetazolamide provocation testing.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 10954270</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Acetazolamide ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Blood Flow Velocity - physiology ; Brain ; Carbonic Anhydrase Inhibitors ; Cardiovascular system ; Carotid Artery, Internal - drug effects ; Carotid Artery, Internal - physiopathology ; Carotid Stenosis - diagnosis ; Carotid Stenosis - physiopathology ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Middle Cerebral Artery - drug effects ; Middle Cerebral Artery - physiopathology ; Predictive Value of Tests ; Ultrasonic investigative techniques ; Ultrasonography, Doppler, Transcranial ; Vasodilation - drug effects ; Vasodilation - physiology</subject><ispartof>American journal of neuroradiology : AJNR, 2000-08, Vol.21 (7), p.1207-1211</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174897/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174897/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1455629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10954270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schreiber, Stephan J</creatorcontrib><creatorcontrib>Gottschalk, Stefan</creatorcontrib><creatorcontrib>Weih, Markus</creatorcontrib><creatorcontrib>Villringer, Arno</creatorcontrib><creatorcontrib>Valdueza, Jose M</creatorcontrib><title>Assessment of Blood Flow Velocity and Diameter of the Middle Cerebral Artery during the Acetazolamide Provocation Test by Use of Transcranial Doppler Sonography and MR Imaging</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Our purpose was to show changes in the diameter of the M1 segment of the middle cerebral artery (MCA) by using high-resolution MR imaging in patients with chronic internal carotid artery occlusion after IV administered acetazolamide challenge. Changes in blood flow velocity of the basal cerebral arteries are thought to correlate with changes of cerebral blood flow. Changes in the diameter of the basal cerebral arteries, however, might influence the validity of transcranial Doppler measurements.
Eight patients with internal carotid artery occlusion who were undergoing acetazolamide testing for assessment of cerebrovascular vasomotor reactivity were included in the study. Blood flow velocities of both MCAs were measured with transcranial Doppler sonography before and 25 minutes after the administration of acetazolamide. Before and 15 minutes after the administration of medication, MR imaging was performed contralateral to the occlusion side. A T2-weighted turbo-gradient spin-echo sequence was chosen to show a cross section of the M1 segment in high resolution (pixels, 0.27 x 0.29 mm). Based on interpolated data, the smallest and greatest MCA diameters were determined.
We did not find changes in the diameter of the MCA after acetazolamide provocation testing with high-resolution MR imaging in patients with occlusive extracranial carotid artery disease.
The results of our study support the hypothesis that changes in MCA flow velocity measured by transcranial Doppler sonography reflect relative changes in cerebral blood flow after acetazolamide provocation testing.</description><subject>Acetazolamide</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Flow Velocity - physiology</subject><subject>Brain</subject><subject>Carbonic Anhydrase Inhibitors</subject><subject>Cardiovascular system</subject><subject>Carotid Artery, Internal - drug effects</subject><subject>Carotid Artery, Internal - physiopathology</subject><subject>Carotid Stenosis - diagnosis</subject><subject>Carotid Stenosis - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Middle Cerebral Artery - drug effects</subject><subject>Middle Cerebral Artery - physiopathology</subject><subject>Predictive Value of Tests</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcFu1DAQhiMEotvCKyAfELdIthPH8QVp2VKo1AoEC-JmTZxJYuTEi51ttLxUXxGXLhQu9mE-fb_mn0fZiqmiypVQ3x5nK8qUyCtG65PsNMbvlFKhJH-anTCqRMklXWW36xgxxhGnmfiOvHHet-TC-YV8ReeNnQ8EppacWxhxxnDHzAOSa9u2DskGAzYBHFmHNDyQdh_s1P8m1gZn-OkdjLZF8jH4G29gtn4iW4wzaQ7kS8Q73TbAFE16bPKc-93OpZjPfvJ9gN1wH3_9iVyO0Cf3s-xJBy7i8-N_lm0v3m437_OrD-8uN-urfCg4n_OKd7IsmWl4J8oa6rJhCmtK24Ia5Chl1QhTKpTAaCkQU1Mga9m2HEQhsDjLXt9rd_tmxNaketKaehfsCOGgPVj9_2Syg-79ja6ZLGslk-DVURD8j33aWI82GnQOJvT7qCVnKl1GJfDFv0l_I_6cKAEvjwBEA65LTRkbH7hSiIqrh8DB9sNiA-o4gnPJyvSyLJxpqRmnsvgF-eKsIA</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Schreiber, Stephan J</creator><creator>Gottschalk, Stefan</creator><creator>Weih, Markus</creator><creator>Villringer, Arno</creator><creator>Valdueza, Jose M</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000801</creationdate><title>Assessment of Blood Flow Velocity and Diameter of the Middle Cerebral Artery during the Acetazolamide Provocation Test by Use of Transcranial Doppler Sonography and MR Imaging</title><author>Schreiber, Stephan J ; Gottschalk, Stefan ; Weih, Markus ; Villringer, Arno ; Valdueza, Jose M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h322t-62f7441cb2f548a84b19e800d30ce2e776b5c49e7a1045ee019a787dd2a535e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acetazolamide</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Flow Velocity - physiology</topic><topic>Brain</topic><topic>Carbonic Anhydrase Inhibitors</topic><topic>Cardiovascular system</topic><topic>Carotid Artery, Internal - drug effects</topic><topic>Carotid Artery, Internal - physiopathology</topic><topic>Carotid Stenosis - diagnosis</topic><topic>Carotid Stenosis - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Middle Cerebral Artery - drug effects</topic><topic>Middle Cerebral Artery - physiopathology</topic><topic>Predictive Value of Tests</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schreiber, Stephan J</creatorcontrib><creatorcontrib>Gottschalk, Stefan</creatorcontrib><creatorcontrib>Weih, Markus</creatorcontrib><creatorcontrib>Villringer, Arno</creatorcontrib><creatorcontrib>Valdueza, Jose M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schreiber, Stephan J</au><au>Gottschalk, Stefan</au><au>Weih, Markus</au><au>Villringer, Arno</au><au>Valdueza, Jose M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Blood Flow Velocity and Diameter of the Middle Cerebral Artery during the Acetazolamide Provocation Test by Use of Transcranial Doppler Sonography and MR Imaging</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>21</volume><issue>7</issue><spage>1207</spage><epage>1211</epage><pages>1207-1211</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>Our purpose was to show changes in the diameter of the M1 segment of the middle cerebral artery (MCA) by using high-resolution MR imaging in patients with chronic internal carotid artery occlusion after IV administered acetazolamide challenge. Changes in blood flow velocity of the basal cerebral arteries are thought to correlate with changes of cerebral blood flow. Changes in the diameter of the basal cerebral arteries, however, might influence the validity of transcranial Doppler measurements.
Eight patients with internal carotid artery occlusion who were undergoing acetazolamide testing for assessment of cerebrovascular vasomotor reactivity were included in the study. Blood flow velocities of both MCAs were measured with transcranial Doppler sonography before and 25 minutes after the administration of acetazolamide. Before and 15 minutes after the administration of medication, MR imaging was performed contralateral to the occlusion side. A T2-weighted turbo-gradient spin-echo sequence was chosen to show a cross section of the M1 segment in high resolution (pixels, 0.27 x 0.29 mm). Based on interpolated data, the smallest and greatest MCA diameters were determined.
We did not find changes in the diameter of the MCA after acetazolamide provocation testing with high-resolution MR imaging in patients with occlusive extracranial carotid artery disease.
The results of our study support the hypothesis that changes in MCA flow velocity measured by transcranial Doppler sonography reflect relative changes in cerebral blood flow after acetazolamide provocation testing.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>10954270</pmid><tpages>5</tpages></addata></record> |
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| subjects | Acetazolamide Aged Aged, 80 and over Biological and medical sciences Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Brain Carbonic Anhydrase Inhibitors Cardiovascular system Carotid Artery, Internal - drug effects Carotid Artery, Internal - physiopathology Carotid Stenosis - diagnosis Carotid Stenosis - physiopathology Female Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Middle Aged Middle Cerebral Artery - drug effects Middle Cerebral Artery - physiopathology Predictive Value of Tests Ultrasonic investigative techniques Ultrasonography, Doppler, Transcranial Vasodilation - drug effects Vasodilation - physiology |
| title | Assessment of Blood Flow Velocity and Diameter of the Middle Cerebral Artery during the Acetazolamide Provocation Test by Use of Transcranial Doppler Sonography and MR Imaging |
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