Disparate roles of retinoid acid signaling molecules in kidney disease

Retinoid acid (RA) is synthesized mainly in the liver and has multiple functions in development, cell differentiation and proliferation, and regulation of inflammation. RA has been used to treat multiple diseases, such as cancer and skin disorders. The kidney is a major organ for RA metabolism, whic...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2021-05, Vol.320 (5), p.F683-F692
Hauptverfasser:	Chen, Anqun, Liu, Yu, Lu, Yu, Lee, Kyung, He, John Cijiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal models Animals Apoptosis Cell culture Cell Differentiation Cell Proliferation Dosage Humans Inflammation Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - physiopathology Kidney diseases Kidney Diseases - drug therapy Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - physiopathology Krueppel-like factor Matrix metalloproteinase Membrane Proteins - metabolism Phosphodiesterase Phosphodiesterase IV Progenitor cells Protein kinase A Receptors, Retinoic Acid - agonists Receptors, Retinoic Acid - metabolism Review Signal Transduction Skin diseases Stem cells Toxicity Transcription activation Tretinoin - adverse effects Tretinoin - metabolism Tumor necrosis factor-α
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