Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis
The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Renal inv...
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| Veröffentlicht in: | BMJ case reports 2021-06, Vol.14 (6), p.e241422 |
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| creator | Sugimoto, Hikaru Yamaguchi, Yasuko Yumura, Wako Takei, Takashi |
| description | The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Renal involvement was detected early during the IgAV follow-up. He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects. This suggests that precise intervention with early diagnosis and careful renal follow-up may prevent renal failure and that low-dose steroids with azathioprine can be an effective treatment for elderly-onset IgAV with nephritis. |
| doi_str_mv | 10.1136/bcr-2020-241422 |
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Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Renal involvement was detected early during the IgAV follow-up. He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects. This suggests that precise intervention with early diagnosis and careful renal follow-up may prevent renal failure and that low-dose steroids with azathioprine can be an effective treatment for elderly-onset IgAV with nephritis.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2020-241422</identifier><identifier>PMID: 34083191</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Abdomen ; Activities of daily living ; Adrenal Cortex Hormones ; Aged ; Aged, 80 and over ; Antibodies ; Antihypertensives ; Arthritis ; Azathioprine ; Biopsy ; Blood pressure ; Body mass index ; Case Report ; Case reports ; Classification ; Creatinine ; Drug dosages ; Edema ; Fractures ; Hematuria ; Humans ; Hypertension ; IgA Vasculitis ; Immunoglobulin A ; Kidney diseases ; Laboratories ; Male ; Nephritis ; Neutrophils ; Pain ; Patients ; Pediatrics ; Proteins ; Rheumatology ; Skin ; Tuberculosis ; Urinalysis ; Vasculitis - drug therapy</subject><ispartof>BMJ case reports, 2021-06, Vol.14 (6), p.e241422</ispartof><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b456t-fbf7920512974b2e05f1bec80077ec1388d3071941143ed54b080503bcf23bcb3</citedby><cites>FETCH-LOGICAL-b456t-fbf7920512974b2e05f1bec80077ec1388d3071941143ed54b080503bcf23bcb3</cites><orcidid>0000-0002-6468-0127</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174510/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174510/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34083191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugimoto, Hikaru</creatorcontrib><creatorcontrib>Yamaguchi, Yasuko</creatorcontrib><creatorcontrib>Yumura, Wako</creatorcontrib><creatorcontrib>Takei, Takashi</creatorcontrib><title>Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Renal involvement was detected early during the IgAV follow-up. He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects. This suggests that precise intervention with early diagnosis and careful renal follow-up may prevent renal failure and that low-dose steroids with azathioprine can be an effective treatment for elderly-onset IgAV with nephritis.</description><subject>Abdomen</subject><subject>Activities of daily living</subject><subject>Adrenal Cortex Hormones</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Antihypertensives</subject><subject>Arthritis</subject><subject>Azathioprine</subject><subject>Biopsy</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Classification</subject><subject>Creatinine</subject><subject>Drug dosages</subject><subject>Edema</subject><subject>Fractures</subject><subject>Hematuria</subject><subject>Humans</subject><subject>Hypertension</subject><subject>IgA Vasculitis</subject><subject>Immunoglobulin A</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Nephritis</subject><subject>Neutrophils</subject><subject>Pain</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Rheumatology</subject><subject>Skin</subject><subject>Tuberculosis</subject><subject>Urinalysis</subject><subject>Vasculitis - drug therapy</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcFrHCEUxqW0NCHNubci9FaYxKfOOnMphJA2gUAvLfQm6jwzLrPjVt2Ezal_el0mDempHp4-_N7nJz9C3gM7AxCrc-tSwxlnDZcgOX9FjkG1qlE9-_n6xfmInOa8ZnUJkJ0Ub8mRkKwT0MMx-X3lfXDG7amZB5qNx7Kn0dMpPjRDzEhdTCW4mAumGAb6EMpIzaMpY4jbFGakYaZlRFoSmrLBuRymcRowTfsmzhkLvbm7oPcmu90USsiLxYzbMR3ad-SNN1PG06f9hPz4cvX98rq5_fb15vLitrGyXZXGW696zlrgvZKWI2s9WHQdY0qhA9F1g2AKegkgBQ6ttKxjLRPWeV6LFSfk8-K73dkNDq4mTWbS9Q8bk_Y6mqD_vZnDqO_ive5AyRZYNfj4ZJDirx3motdxl-aaWfNWrLhYdaKvqvNF5VLMOaF_fgGYPlDTlZo-UNMLtTrx4WWwZ_1fRlXwaRHYzfq_bn8A0fKixg</recordid><startdate>20210602</startdate><enddate>20210602</enddate><creator>Sugimoto, Hikaru</creator><creator>Yamaguchi, Yasuko</creator><creator>Yumura, Wako</creator><creator>Takei, Takashi</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6468-0127</orcidid></search><sort><creationdate>20210602</creationdate><title>Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis</title><author>Sugimoto, Hikaru ; 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| subjects | Abdomen Activities of daily living Adrenal Cortex Hormones Aged Aged, 80 and over Antibodies Antihypertensives Arthritis Azathioprine Biopsy Blood pressure Body mass index Case Report Case reports Classification Creatinine Drug dosages Edema Fractures Hematuria Humans Hypertension IgA Vasculitis Immunoglobulin A Kidney diseases Laboratories Male Nephritis Neutrophils Pain Patients Pediatrics Proteins Rheumatology Skin Tuberculosis Urinalysis Vasculitis - drug therapy |
| title | Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis |
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