Clinical and radiological characteristics of COVID‑19 patients without comorbidities: A single-center study
Summary Objective To evaluate the clinical characteristics and detailed imaging features in coronavirus disease 2019 (COVID-19) patients without comorbidities. Material and methods This retrospective study included laboratory-confirmed and symptomatic COVID-19 patients without comorbid diseases who...
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| Veröffentlicht in: | Wiener Klinische Wochenschrift 2021-09, Vol.133 (17-18), p.875-881 |
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| container_issue | 17-18 |
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| container_title | Wiener Klinische Wochenschrift |
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| creator | Ozturk, Saffet Kurtulus Ozturk, Esin Yildiz Kaya, Sibel |
| description | Summary
Objective
To evaluate the clinical characteristics and detailed imaging features in coronavirus disease 2019 (COVID-19) patients without comorbidities.
Material and methods
This retrospective study included laboratory-confirmed and symptomatic COVID-19 patients without comorbid diseases who were admitted to our second level hospital between March 2020 and September 2020. We assessed the clinical, biochemical and imaging diagnostic parameters on admission. The patients were classified as non-severe and progress to severe group and then the initial parameters were compared.
Results
We enrolled 135 adult COVID-19 patients, 12 progressed to severe disease during hospitalization. Compared to the non-severe group, patients who progressed to severe were older (
p
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| doi_str_mv | 10.1007/s00508-021-01880-5 |
| format | Article |
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Objective
To evaluate the clinical characteristics and detailed imaging features in coronavirus disease 2019 (COVID-19) patients without comorbidities.
Material and methods
This retrospective study included laboratory-confirmed and symptomatic COVID-19 patients without comorbid diseases who were admitted to our second level hospital between March 2020 and September 2020. We assessed the clinical, biochemical and imaging diagnostic parameters on admission. The patients were classified as non-severe and progress to severe group and then the initial parameters were compared.
Results
We enrolled 135 adult COVID-19 patients, 12 progressed to severe disease during hospitalization. Compared to the non-severe group, patients who progressed to severe were older (
p
< 0.001) and were more likely to manifest coughing (
p
= 0.011) and have higher lactate dehydrogenase (LDH) levels (
p
= 0.011). On chest computed tomography (CT) images, multilobar (
p
= 0.016), peripherally (
p
= 0.001) distributed mixed ground glass opacities and consolidation (
p
< 0.001), crazy paving (
p
= 0.007) and higher total CT severity score (
p
< 0.001) were significantly associated with severe disease.
Conclusion
Knowledge of the clinical and radiological parameters associated with disease severity might be useful to guide clinical decision-making for COVID-19 patients without comorbidities.</description><identifier>ISSN: 0043-5325</identifier><identifier>EISSN: 1613-7671</identifier><identifier>DOI: 10.1007/s00508-021-01880-5</identifier><identifier>PMID: 34081191</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Endocrinology ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Pneumology/Respiratory System</subject><ispartof>Wiener Klinische Wochenschrift, 2021-09, Vol.133 (17-18), p.875-881</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c330t-d98661b076a31b06c68640c0b1b518c54953e82e9f6af3d9101272fb5bec00293</cites><orcidid>0000-0002-5221-4831 ; 0000-0001-6046-3486 ; 0000-0002-6319-7889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00508-021-01880-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00508-021-01880-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Ozturk, Saffet</creatorcontrib><creatorcontrib>Kurtulus Ozturk, Esin</creatorcontrib><creatorcontrib>Yildiz Kaya, Sibel</creatorcontrib><title>Clinical and radiological characteristics of COVID‑19 patients without comorbidities: A single-center study</title><title>Wiener Klinische Wochenschrift</title><addtitle>Wien Klin Wochenschr</addtitle><description>Summary
Objective
To evaluate the clinical characteristics and detailed imaging features in coronavirus disease 2019 (COVID-19) patients without comorbidities.
Material and methods
This retrospective study included laboratory-confirmed and symptomatic COVID-19 patients without comorbid diseases who were admitted to our second level hospital between March 2020 and September 2020. We assessed the clinical, biochemical and imaging diagnostic parameters on admission. The patients were classified as non-severe and progress to severe group and then the initial parameters were compared.
Results
We enrolled 135 adult COVID-19 patients, 12 progressed to severe disease during hospitalization. Compared to the non-severe group, patients who progressed to severe were older (
p
< 0.001) and were more likely to manifest coughing (
p
= 0.011) and have higher lactate dehydrogenase (LDH) levels (
p
= 0.011). On chest computed tomography (CT) images, multilobar (
p
= 0.016), peripherally (
p
= 0.001) distributed mixed ground glass opacities and consolidation (
p
< 0.001), crazy paving (
p
= 0.007) and higher total CT severity score (
p
< 0.001) were significantly associated with severe disease.
Conclusion
Knowledge of the clinical and radiological parameters associated with disease severity might be useful to guide clinical decision-making for COVID-19 patients without comorbidities.</description><subject>Endocrinology</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Pneumology/Respiratory System</subject><issn>0043-5325</issn><issn>1613-7671</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UbtOxDAQtBAIjoMfoEpJE9i1Y8dpkNDxlJBogNZyHOfOKBcfdgKi4xf4Rb4EwyEkGqqVZmdmVzOEHCAcIUB5HAE4yBwo5oBSQs43yAQFsrwUJW6SCUDBcs4o3yG7MT4CMF6UuE12WAESscIJeZh1rndGd5numyzoxvnOz78Bs9BBm8EGFwdnYubbbHb7cH328faOVbbSg7P9ELMXNyz8OGTGL32oXeMSHvfIVqu7aPd_5pTcX5zfza7ym9vL69npTW4YgyFvKikE1lAKzdIQRkhRgIEaa47S8KLizEpqq1boljUVAtKStjWvrQGgFZuSk7XvaqyXtjHpo6A7tQpuqcOr8tqpv5veLdTcPyuJJeMpnik5_DEI_mm0cVBLF43tOt1bP0ZFORMSsOA0UemaaoKPMdj29wyC-ipErQtRqRD1XYjiScTWopjI_dwG9ejH0KdM_lN9Ah7Vjgs</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Ozturk, Saffet</creator><creator>Kurtulus Ozturk, Esin</creator><creator>Yildiz Kaya, Sibel</creator><general>Springer Vienna</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5221-4831</orcidid><orcidid>https://orcid.org/0000-0001-6046-3486</orcidid><orcidid>https://orcid.org/0000-0002-6319-7889</orcidid></search><sort><creationdate>20210901</creationdate><title>Clinical and radiological characteristics of COVID‑19 patients without comorbidities</title><author>Ozturk, Saffet ; Kurtulus Ozturk, Esin ; Yildiz Kaya, Sibel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-d98661b076a31b06c68640c0b1b518c54953e82e9f6af3d9101272fb5bec00293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Endocrinology</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Pneumology/Respiratory System</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozturk, Saffet</creatorcontrib><creatorcontrib>Kurtulus Ozturk, Esin</creatorcontrib><creatorcontrib>Yildiz Kaya, Sibel</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiener Klinische Wochenschrift</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozturk, Saffet</au><au>Kurtulus Ozturk, Esin</au><au>Yildiz Kaya, Sibel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and radiological characteristics of COVID‑19 patients without comorbidities: A single-center study</atitle><jtitle>Wiener Klinische Wochenschrift</jtitle><stitle>Wien Klin Wochenschr</stitle><date>2021-09-01</date><risdate>2021</risdate><volume>133</volume><issue>17-18</issue><spage>875</spage><epage>881</epage><pages>875-881</pages><issn>0043-5325</issn><eissn>1613-7671</eissn><abstract>Summary
Objective
To evaluate the clinical characteristics and detailed imaging features in coronavirus disease 2019 (COVID-19) patients without comorbidities.
Material and methods
This retrospective study included laboratory-confirmed and symptomatic COVID-19 patients without comorbid diseases who were admitted to our second level hospital between March 2020 and September 2020. We assessed the clinical, biochemical and imaging diagnostic parameters on admission. The patients were classified as non-severe and progress to severe group and then the initial parameters were compared.
Results
We enrolled 135 adult COVID-19 patients, 12 progressed to severe disease during hospitalization. Compared to the non-severe group, patients who progressed to severe were older (
p
< 0.001) and were more likely to manifest coughing (
p
= 0.011) and have higher lactate dehydrogenase (LDH) levels (
p
= 0.011). On chest computed tomography (CT) images, multilobar (
p
= 0.016), peripherally (
p
= 0.001) distributed mixed ground glass opacities and consolidation (
p
< 0.001), crazy paving (
p
= 0.007) and higher total CT severity score (
p
< 0.001) were significantly associated with severe disease.
Conclusion
Knowledge of the clinical and radiological parameters associated with disease severity might be useful to guide clinical decision-making for COVID-19 patients without comorbidities.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>34081191</pmid><doi>10.1007/s00508-021-01880-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5221-4831</orcidid><orcidid>https://orcid.org/0000-0001-6046-3486</orcidid><orcidid>https://orcid.org/0000-0002-6319-7889</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0043-5325 1613-7671 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Endocrinology Gastroenterology Internal Medicine Medicine Medicine & Public Health Original Original Article Pneumology/Respiratory System |
| title | Clinical and radiological characteristics of COVID‑19 patients without comorbidities: A single-center study |
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