Modification of amyloid-beta peptide aggregation via photoactivation of strained Ru( ii ) polypyridyl complexes

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive and irreversible damage to the brain. One of the hallmarks of the disease is the presence of both soluble and insoluble aggregates of the amyloid beta (Aβ) peptide in the brain, and these aggregates ar...

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Veröffentlicht in:	Chemical science (Cambridge) 2021-04, Vol.12 (21), p.7510-7520
Hauptverfasser:	Bataglioli, Janaina C., Gomes, Luiza M. F., Maunoir, Camille, Smith, Jason R., Cole, Houston D., McCain, Julia, Sainuddin, Tariq, Cameron, Colin G., McFarland, Sherri A., Storr, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Aggregates Alzheimer's disease Binding Brain damage Chemistry Ligands Morphology Peptides Ruthenium compounds Size distribution Toxicity
Online-Zugang:	Volltext
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