Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B

Rationale: Differential activation of macrophages correlates closely with tumor progression, and the epigenetic factor lysine demethylase 6B (KDM6B, previously named JMJD3) mediates the regulation of macrophage polarization through an unknown mechanism. Methods: We developed a suspension coculture s...

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Veröffentlicht in:	Theranostics 2021-01, Vol.11 (14), p.6847-6859
Hauptverfasser:	Xun, Jing, Du, Lingfang, Gao, Ruifang, Shen, Long, Wang, Dekun, Kang, Lichun, Chen, Chuan'ai, Zhang, Zhujun, Zhang, Yuying, Yue, Shijing, Feng, Shuxin, Xiang, Rong, Mi, Xue, Tan, Xiaoyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Breast cancer Epigenetics Gene expression Metastasis Research Paper Signal transduction
Online-Zugang:	Volltext
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