Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

The identification of CD4 T cell epitopes is instrumental for the design of subunit vaccines for broad protection against coronaviruses. Here we demonstrate in COVID-19-recovered individuals a robust CD4 T cell response to naturally processed SARS-CoV-2 spike (S) and nucleoprotein (N), including eff...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-06, Vol.372 (6548), p.1336-1341
Hauptverfasser:	Low, Jun Siong, Vaqueirinho, Daniela, Mele, Federico, Foglierini, Mathilde, Jerak, Josipa, Perotti, Michela, Jarrossay, David, Jovic, Sandra, Perez, Laurent, Cacciatore, Rosalia, Terrot, Tatiana, Pellanda, Alessandra Franzetti, Biggiogero, Maira, Garzoni, Christian, Ferrari, Paolo, Ceschi, Alessandro, Lanzavecchia, Antonio, Sallusto, Federica, Cassotta, Antonino
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Binding CD4 antigen Coronaviridae Coronaviruses COVID-19 COVID-19 vaccines Cross-reactivity Epitopes Histocompatibility antigen HLA Immunodominance Immunogenicity Immunological memory Immunology Leukocytes Lymphocytes Lymphocytes T Medicine Memory Memory cells Proteins Receptors Respiratory diseases Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Vaccines Viral diseases
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