Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose
SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA v...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2021-06, Vol.372 (6549), p.1418-1423 |
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| creator | Reynolds, Catherine J Pade, Corinna Gibbons, Joseph M Butler, David K Otter, Ashley D Menacho, Katia Fontana, Marianna Smit, Angelique Sackville-West, Jane E Cutino-Moguel, Teresa Maini, Mala K Chain, Benjamin Noursadeghi, Mahdad Brooks, Tim Semper, Amanda Manisty, Charlotte Treibel, Thomas A Moon, James C Valdes, Ana M McKnight, Áine Altmann, Daniel M Boyton, Rosemary |
| description | SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants. |
| doi_str_mv | 10.1126/science.abh1282 |
| format | Article |
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We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.abh1282</identifier><identifier>PMID: 33931567</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Antibodies ; Antigens ; Clinical trials ; Coronaviruses ; COVID-19 ; Genotyping ; Health care ; Heterogeneity ; Histocompatibility antigen HLA ; Immunity ; Immunological memory ; Immunology ; Infections ; Leukocytes ; Lymphocytes ; Lymphocytes T ; Medical personnel ; Memory cells ; mRNA ; mRNA vaccines ; Mutation ; Neutralizing ; Pandemics ; Respiratory diseases ; Ribonucleic acid ; RNA ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Spike protein ; Vaccines ; Viral diseases ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 2021-06, Vol.372 (6549), p.1418-1423</ispartof><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. 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We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Clinical trials</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Genotyping</subject><subject>Health care</subject><subject>Heterogeneity</subject><subject>Histocompatibility antigen HLA</subject><subject>Immunity</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Infections</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical personnel</subject><subject>Memory cells</subject><subject>mRNA</subject><subject>mRNA vaccines</subject><subject>Mutation</subject><subject>Neutralizing</subject><subject>Pandemics</subject><subject>Respiratory diseases</subject><subject>Ribonucleic 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We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. 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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2021-06, Vol.372 (6549), p.1418-1423 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8168614 |
| source | Science Magazine |
| subjects | Antibodies Antigens Clinical trials Coronaviruses COVID-19 Genotyping Health care Heterogeneity Histocompatibility antigen HLA Immunity Immunological memory Immunology Infections Leukocytes Lymphocytes Lymphocytes T Medical personnel Memory cells mRNA mRNA vaccines Mutation Neutralizing Pandemics Respiratory diseases Ribonucleic acid RNA Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Vaccines Viral diseases Viruses |
| title | Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T07%3A49%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prior%20SARS-CoV-2%20infection%20rescues%20B%20and%20T%20cell%20responses%20to%20variants%20after%20first%20vaccine%20dose&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Reynolds,%20Catherine%20J&rft.aucorp=UK%20COVIDsortium%20Investigators&rft.date=2021-06-25&rft.volume=372&rft.issue=6549&rft.spage=1418&rft.epage=1423&rft.pages=1418-1423&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.abh1282&rft_dat=%3Cproquest_pubme%3E2520852632%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2544930338&rft_id=info:pmid/33931567&rfr_iscdi=true |