Synthetic proteins for COVID-19 diagnostics

•Synthetic protein (JS7) and peptides bind serum antibodies of COVID-19 patients.•JS7 represents the interface of SARS-CoV-2 receptor binding domain with ACE2.•Antibody binding to JS7 or recombinant RBD is proportional to disease severity.•RBD/ACE2 interface peptides block antibody binding to JS7 or...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2021-09, Vol.143, p.170583-170583, Article 170583
Hauptverfasser:	Schein, Catherine H., Levine, Corri B., McLellan, Susan L.F., Negi, Surendra S., Braun, Werner, Dreskin, Stephen C., Anaya, Elizabeth S., Schmidt, Jurgen
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 interaction Angiotensin-Converting Enzyme 2 - chemistry BASIC BIOLOGICAL SCIENCES Biological Science COVID diagnostic, Synthetic antigens COVID-19 COVID-19 Serological Testing COVID-19 variants Humans Neutralizing antibodies Peptide vaccines Peptides - chemistry Protein Domains Receptor binding domain S protein epitopes SARS-CoV-2 Spike Glycoprotein, Coronavirus - chemistry Structure based design
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