Design and synthesis of isothiocyanate‐containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH–Deficient prostate cancer cells

Sustained androgen receptor (AR) signaling and apoptosis evasion are among the main hurdles of castration‐resistant prostate cancer (CRPC) treatment. We designed and synthesized isothiocyanate (ITC)‐containing hybrid AR antagonist (ITC‐ARi) and rationally combined ITC‐ARi with GSH synthesis inhibito...

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Veröffentlicht in:	Chemical biology & drug design 2021-05, Vol.97 (5), p.1059-1078
Hauptverfasser:	Qin, Zhihui, Ou, Siyu, Xu, Liping, Sorensen, Kathleen, Zhang, Yingxue, Hu, Dan‐Ping, Yang, Zhe, Hu, Wen‐Yang, Chen, Fei, Prins, Gail S.
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor androgen receptor splice variant 7 BSO castration‐resistant prostate cancer drug combination ferroptosis GSH hybrid androgen receptor antagonist hybrid drug isothiocyanate
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