LGG-11. BH3-MIMETICS TARGETING BCL-XL SELECTIVELY IMPACT THE SENESCENT COMPARTMENT OF PILOCYTIC ASTROCYTOMA

Abstract Introduction Pilocytic astrocytoma (PA) is the most common brain tumor in children. Activation of the mitogen-activated protein kinase (MAPK) pathway is a hallmark of PA. Complete remission in non-resectable tumors is infrequently observed with current therapeutic approaches. Most PA tumors...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2021-06, Vol.23 (Supplement_1), p.i33-i34
Hauptverfasser:	Selt, Florian, Sigaud, Romain, Sievers, Philipp, Zaman, Julia, Peterziel, Heike, Tsai, Jessica W, Guiho, Romain, Martínez-Barbera, Juan Pedro, Pusch, Stefan, Schuhmann, Martin U, El Damaty, Ahmed, Bandopadhayay, Pratiti, Pfister, Stefan M, Oehme, Ina, Sahm, Felix, Jones, David T W, Witt, Olaf, Milde, Till
Format:	Artikel
Sprache:	eng
Schlagworte:	Low Grade Gliomas
Online-Zugang:	Volltext
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