Poly(U)‐specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element‐mediated inhibition

Upstream open reading frames (uORFs) are known to negatively affect translation of the downstream ORF. The regulatory proteins involved in relieving this inhibition are however poorly characterized. In response to cellular stress, eIF2α phosphorylation leads to an inhibition of global protein synthe...

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Veröffentlicht in:	The EMBO journal 2021-06, Vol.40 (11), p.e104123-n/a
Hauptverfasser:	Lee, Hung‐Chieh, Fu, Chuan‐Yang, Lin, Cheng‐Yung, Hu, Jia‐Rung, Huang, Ting‐Ying, Lo, Kai‐Yin, Tsai, Hsin‐Yue, Sheu, Jin‐Chuan, Tsai, Huai‐Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	CHOP CHOP protein Cleavage EMBO32 Heat shock human ENDOU‐1 Internal ribosome entry site Kinases Open reading frames Phosphorylation Polyuridine Protein biosynthesis Protein synthesis Proteins Regulatory proteins Releasing Ribosomes Translation translational control uORF Upstream Zebrafish Zebrafish Endouc
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