B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases. Therefore, understanding how different receptors on T cells impact functional outcomes is crucial. The influence of B7-H7 (HHLA2) and CD28H (TMIGD2) on T-cell activation remains controversial. Here we e...

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Veröffentlicht in:	Cellular & molecular immunology 2021-06, Vol.18 (6), p.1503-1511
Hauptverfasser:	Rieder, Sadiye Amcaoglu, Wang, Jingya, White, Natalie, Qadri, Ariful, Menard, Catherine, Stephens, Geoffrey, Karnell, Jodi L., Rudd, Christopher E., Kolbeck, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/1619 631/250/2152 Antibodies Antigen-presenting cells Autoimmune diseases B7 antigen B7-1 antigen Biomedical and Life Sciences Biomedicine CD28 antigen CD28 Antigens - metabolism Cell activation Cell Proliferation Cytokines Gene Expression Regulation Humans Immunoglobulins - metabolism Immunology Lymphocyte Activation - immunology Lymphocyte Culture Test, Mixed Lymphocytes Lymphocytes T Medical Microbiology Microbiology Models, Biological PD-L1 protein Protein Binding Receptors, Antigen, T-Cell - metabolism Signal Transduction T cell receptors T-Lymphocytes - cytology T-Lymphocytes - immunology Transcription Vaccine
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