Age-at-Onset and APOE-Related Heterogeneity in Pathologically Confirmed Sporadic Alzheimer Disease

To characterize age-related clinical heterogeneity in Alzheimer disease (AD) and determine whether it is modified by genotype or concomitant non-AD pathology, we analyzed data from 1,750 patients with sporadic, pathologically confirmed severe AD. In this retrospective cohort study, regression and mi...

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Veröffentlicht in:	Neurology 2021-05, Vol.96 (18), p.e2272-e2283
Hauptverfasser:	Smirnov, Denis S., Galasko, Douglas, Hiniker, Annie, Edland, Steven D., Salmon, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer Disease - pathology Apolipoproteins E - genetics Female Genetic Heterogeneity Humans Male Middle Aged Retrospective Studies
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