Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8⁺ regulatory T cells

Colorectal cancer (CRC) represents the third most common malignancy and the second leading cause of cancer-related deaths worldwide. Although immunotherapy has taken center stage in mainstream oncology, it has shown limited clinical efficacy in CRC, generating an urgent need for discovery of new bio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-05, Vol.118 (21), p.1-11
Hauptverfasser:	Cagnoni, Alejandro J., Giribaldi, María Laura, Blidner, Ada G., Cutine, Anabela M., Gatto, Sabrina G., Morales, Rosa M., Salatino, Mariana, Abba, Martín C., Croci, Diego O., Mariño, Karina V., Rabinovich, Gabriel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Azoxymethane Biological Sciences Biomarkers Cancer CD122 antigen CD8 antigen Colitis Colorectal cancer Colorectal carcinoma Dextran Dextrans Galectin-1 Genomes Glycan Immunoregulation Immunotherapy Lymphocytes Lymphocytes T Malignancy Microenvironments PD-1 protein Sodium sulfate Tumors
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