Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal

Chronic administration of opioids produces physical dependence and opioid-induced hyperalgesia. Users claim the Thai traditional tea “kratom” and component alkaloid mitragynine ameliorate opioid withdrawal without increased sensitivity to pain. Testing these claims, we assessed the combined kratom a...

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Veröffentlicht in:	Cellular and molecular neurobiology 2021-07, Vol.41 (5), p.1131-1143
Hauptverfasser:	Wilson, Lisa L., Chakraborty, Soumen, Eans, Shainnel O., Cirino, Thomas J., Stacy, Heather M., Simons, Chloe A., Uprety, Rajendra, Majumdar, Susruta, McLaughlin, Jay P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Animals Biomedical and Life Sciences Biomedicine Cell Biology Dosage Drug dependence Drug dosages Drug withdrawal Male Mice Mice, Inbred C57BL Mitragyna Morphine Morphine Dependence - metabolism Morphine Dependence - prevention & control Morphine Dependence - psychology Naloxone Narcotics Neurobiology Neurosciences Opioids Original Research Pain Measurement - drug effects Pain Measurement - methods Pain perception Receptors, Opioid, delta - agonists Receptors, Opioid, delta - metabolism Receptors, Opioid, mu - agonists Receptors, Opioid, mu - metabolism Secologanin Tryptamine Alkaloids - administration & dosage Secologanin Tryptamine Alkaloids - adverse effects Secologanin Tryptamine Alkaloids - chemical synthesis Secologanin Tryptamine Alkaloids - isolation & purification Sensitivity analysis Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - prevention & control Substance Withdrawal Syndrome - psychology
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