Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease

Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA and surface protein data from 500,089 memory T cells to define 31 cell states from 259 individuals in a Peruvian tuberculosis (TB) progression cohort. A...

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Veröffentlicht in:	Nature immunology 2021-06, Vol.22 (6), p.781-793
Hauptverfasser:	Nathan, Aparna, Beynor, Jessica I., Baglaenko, Yuriy, Suliman, Sara, Ishigaki, Kazuyoshi, Asgari, Samira, Huang, Chuan-Chin, Luo, Yang, Zhang, Zibiao, Lopez, Kattya, Lindestam Arlehamn, Cecilia S., Ernst, Joel D., Jimenez, Judith, Calderón, Roger I., Lecca, Leonid, Van Rhijn, Ildiko, Moody, D. Branch, Murray, Megan B., Raychaudhuri, Soumya
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/248 631/250/2520 631/250/255/1856 631/61/514 Adolescent Adult Age Factors Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Case-Control Studies Child Demographic aspects Demography Development and progression Disease Progression Female Follow-Up Studies Genetic Predisposition to Disease Genotyping Techniques Health aspects Helper cells Humans Identification and classification Immunologic Memory Immunological memory Immunology Infectious Diseases Lymphocytes Lymphocytes T Male Memory cells Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - isolation & purification Peptides Peru Resource RNA-Seq Sex Factors Single-Cell Analysis Socioeconomic Factors Statistics T cells Th17 Cells - immunology Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Young Adult
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