Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation

Immune checkpoint inhibitors (ICIs) are revolutionizing cancer treatment. Nevertheless, their increasing use leads to an increase of immune-related adverse events (irAEs). Among them, ICI-associated myocarditis (ICIM) is a rare irAE with a high mortality rate. We aimed to characterize the transcript...

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Veröffentlicht in:	Cancers 2021-05, Vol.13 (10), p.2498
Hauptverfasser:	Finke, Daniel, Heckmann, Markus B, Salatzki, Janek, Riffel, Johannes, Herpel, Esther, Heinzerling, Lucie M, Meder, Benjamin, Völkers, Mirko, Müller, Oliver J, Frey, Norbert, Katus, Hugo A, Leuschner, Florian, Kaya, Ziya, Lehmann, Lorenz H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Biopsy Cardiomyocytes Cardiomyopathy Dilated cardiomyopathy Gadolinium Gene expression Heart Heart diseases Hospitals Immune checkpoint inhibitors Inflammasomes Kinases Laboratories Lymphocytes Mortality Myocarditis Patients Ribonucleic acid RNA Transcription Transcriptomics Ventricle γ-Interferon
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