Association of daily step count and serum testosterone among men in the United States
Purpose To describe the association between daily activity (i.e., daily step counts and accelerometer intensity measures) and serum TT levels in a representative sample of US adults aged 18 years or older. Methods A retrospective cohort study was carried out utilizing the NHANES (National Health and...
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| Veröffentlicht in: | Endocrine 2021-06, Vol.72 (3), p.874-881 |
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| creator | Del Giudice, Francesco Glover, Frank Belladelli, Federico De Berardinis, Ettore Sciarra, Alessandro Salciccia, Stefano Kasman, Alex M. Chen, Tony Eisenberg, Michael L. |
| description | Purpose
To describe the association between daily activity (i.e., daily step counts and accelerometer intensity measures) and serum TT levels in a representative sample of US adults aged 18 years or older.
Methods
A retrospective cohort study was carried out utilizing the NHANES (National Health and Nutrition Examination Survey) 2003–2004 cycle. Physical activity was measured with a waist-worn uniaxial accelerometer (AM-7164; ActiGraph) for up to 7 days using a standardized protocol. Using linear and multivariable logistic regression controlling for relevant social, demographic, lifestyle, and comorbidity characteristics, we assessed the association between daily step counts and TT.
Results
A total of 279 subjects with a median age 46 (IQR: 33–56) were included in the analysis. 23.3% of the cohort had a low serum TT level (TT 8000 steps/day had a lower odd of being hypogonadal (OR 0.14, 95% CI: 0.07–0.49 and 0.08, 95%CI: 0.02–0.44, respectively). While a threshold effect was noted on average, TT increased 7 ng/dL for each additional 1000 steps taken daily (β-estimate: 0.007, 95% CI: 0.002–0.013).
Conclusions
Patients with the lowest daily step counts had higher odds of being hypogonadal. The current work supports a possible association between daily steps, total testosterone, and hypogonadism for men in the US. |
| doi_str_mv | 10.1007/s12020-021-02631-2 |
| format | Article |
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To describe the association between daily activity (i.e., daily step counts and accelerometer intensity measures) and serum TT levels in a representative sample of US adults aged 18 years or older.
Methods
A retrospective cohort study was carried out utilizing the NHANES (National Health and Nutrition Examination Survey) 2003–2004 cycle. Physical activity was measured with a waist-worn uniaxial accelerometer (AM-7164; ActiGraph) for up to 7 days using a standardized protocol. Using linear and multivariable logistic regression controlling for relevant social, demographic, lifestyle, and comorbidity characteristics, we assessed the association between daily step counts and TT.
Results
A total of 279 subjects with a median age 46 (IQR: 33–56) were included in the analysis. 23.3% of the cohort had a low serum TT level (TT < 350 ng/dl). Compared to men who took <4000 steps per day, men who took >4000 or >8000 steps/day had a lower odd of being hypogonadal (OR 0.14, 95% CI: 0.07–0.49 and 0.08, 95%CI: 0.02–0.44, respectively). While a threshold effect was noted on average, TT increased 7 ng/dL for each additional 1000 steps taken daily (β-estimate: 0.007, 95% CI: 0.002–0.013).
Conclusions
Patients with the lowest daily step counts had higher odds of being hypogonadal. The current work supports a possible association between daily steps, total testosterone, and hypogonadism for men in the US.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-021-02631-2</identifier><identifier>PMID: 33580402</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Diabetes ; Endocrinology ; Humanities and Social Sciences ; Hypogonadism ; Internal Medicine ; Medicine ; Medicine & Public Health ; multidisciplinary ; Original ; Original Article ; Physical activity ; Science ; Testosterone</subject><ispartof>Endocrine, 2021-06, Vol.72 (3), p.874-881</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9237f1aefbe810414d1f3ed7ea5f585e0ca51ff62aa03c2f5b095507797193d73</citedby><cites>FETCH-LOGICAL-c474t-9237f1aefbe810414d1f3ed7ea5f585e0ca51ff62aa03c2f5b095507797193d73</cites><orcidid>0000-0003-3865-5988</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-021-02631-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-021-02631-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33580402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Del Giudice, Francesco</creatorcontrib><creatorcontrib>Glover, Frank</creatorcontrib><creatorcontrib>Belladelli, Federico</creatorcontrib><creatorcontrib>De Berardinis, Ettore</creatorcontrib><creatorcontrib>Sciarra, Alessandro</creatorcontrib><creatorcontrib>Salciccia, Stefano</creatorcontrib><creatorcontrib>Kasman, Alex M.</creatorcontrib><creatorcontrib>Chen, Tony</creatorcontrib><creatorcontrib>Eisenberg, Michael L.</creatorcontrib><title>Association of daily step count and serum testosterone among men in the United States</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
To describe the association between daily activity (i.e., daily step counts and accelerometer intensity measures) and serum TT levels in a representative sample of US adults aged 18 years or older.
Methods
A retrospective cohort study was carried out utilizing the NHANES (National Health and Nutrition Examination Survey) 2003–2004 cycle. Physical activity was measured with a waist-worn uniaxial accelerometer (AM-7164; ActiGraph) for up to 7 days using a standardized protocol. Using linear and multivariable logistic regression controlling for relevant social, demographic, lifestyle, and comorbidity characteristics, we assessed the association between daily step counts and TT.
Results
A total of 279 subjects with a median age 46 (IQR: 33–56) were included in the analysis. 23.3% of the cohort had a low serum TT level (TT < 350 ng/dl). Compared to men who took <4000 steps per day, men who took >4000 or >8000 steps/day had a lower odd of being hypogonadal (OR 0.14, 95% CI: 0.07–0.49 and 0.08, 95%CI: 0.02–0.44, respectively). While a threshold effect was noted on average, TT increased 7 ng/dL for each additional 1000 steps taken daily (β-estimate: 0.007, 95% CI: 0.002–0.013).
Conclusions
Patients with the lowest daily step counts had higher odds of being hypogonadal. The current work supports a possible association between daily steps, total testosterone, and hypogonadism for men in the US.</description><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Humanities and Social Sciences</subject><subject>Hypogonadism</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Original</subject><subject>Original Article</subject><subject>Physical activity</subject><subject>Science</subject><subject>Testosterone</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kc1rFTEUxYMo9kP_ARcScONm9OZmMpnZCKVoFQou9IG7kDdz85oykzyTjND_3rSv1o-Fi5DAOfd3cziMvRDwRgDot1kgIDSAop5OigYfsWOh1NBA1R_Xt1SqAei_HbGTnK8BELHTT9mRlKqHFvCYbc5yjqO3xcfAo-OT9fMNz4X2fIxrKNyGiWdK68IL5RKrkmIgbpcYdnyhwH3g5Yr4JvhCE_9SbPU9Y0-cnTM9v79P2ebD-6_nH5vLzxefzs8um7HVbWkGlNoJS25LvYBWtJNwkiZNVjnVK4LRKuFch9aCHNGpLQxKgdaDFoOctDxl7w7c_bpdaBoplGRns09-senGROvN30rwV2YXf5heqEH3fQW8vgek-H2tAc3i80jzbAPFNRts-wEVqvZ216t_rNdxTaHGM6iklB12d0A8uMYUc07kHj4jwNy2Zg6tmdqauWvNYB16-WeMh5FfNVWDPBhylcKO0u_d_8H-BPDroxw</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Del Giudice, Francesco</creator><creator>Glover, Frank</creator><creator>Belladelli, Federico</creator><creator>De Berardinis, Ettore</creator><creator>Sciarra, Alessandro</creator><creator>Salciccia, Stefano</creator><creator>Kasman, Alex M.</creator><creator>Chen, Tony</creator><creator>Eisenberg, Michael L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3865-5988</orcidid></search><sort><creationdate>20210601</creationdate><title>Association of daily step count and serum testosterone among men in the United States</title><author>Del Giudice, Francesco ; Glover, Frank ; Belladelli, Federico ; De Berardinis, Ettore ; Sciarra, Alessandro ; Salciccia, Stefano ; Kasman, Alex M. ; Chen, Tony ; Eisenberg, Michael L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9237f1aefbe810414d1f3ed7ea5f585e0ca51ff62aa03c2f5b095507797193d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Humanities and Social Sciences</topic><topic>Hypogonadism</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Original</topic><topic>Original Article</topic><topic>Physical activity</topic><topic>Science</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Del Giudice, Francesco</creatorcontrib><creatorcontrib>Glover, Frank</creatorcontrib><creatorcontrib>Belladelli, Federico</creatorcontrib><creatorcontrib>De Berardinis, Ettore</creatorcontrib><creatorcontrib>Sciarra, Alessandro</creatorcontrib><creatorcontrib>Salciccia, Stefano</creatorcontrib><creatorcontrib>Kasman, Alex M.</creatorcontrib><creatorcontrib>Chen, Tony</creatorcontrib><creatorcontrib>Eisenberg, Michael L.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Del Giudice, Francesco</au><au>Glover, Frank</au><au>Belladelli, Federico</au><au>De Berardinis, Ettore</au><au>Sciarra, Alessandro</au><au>Salciccia, Stefano</au><au>Kasman, Alex M.</au><au>Chen, Tony</au><au>Eisenberg, Michael L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of daily step count and serum testosterone among men in the United States</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>72</volume><issue>3</issue><spage>874</spage><epage>881</epage><pages>874-881</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
To describe the association between daily activity (i.e., daily step counts and accelerometer intensity measures) and serum TT levels in a representative sample of US adults aged 18 years or older.
Methods
A retrospective cohort study was carried out utilizing the NHANES (National Health and Nutrition Examination Survey) 2003–2004 cycle. Physical activity was measured with a waist-worn uniaxial accelerometer (AM-7164; ActiGraph) for up to 7 days using a standardized protocol. Using linear and multivariable logistic regression controlling for relevant social, demographic, lifestyle, and comorbidity characteristics, we assessed the association between daily step counts and TT.
Results
A total of 279 subjects with a median age 46 (IQR: 33–56) were included in the analysis. 23.3% of the cohort had a low serum TT level (TT < 350 ng/dl). Compared to men who took <4000 steps per day, men who took >4000 or >8000 steps/day had a lower odd of being hypogonadal (OR 0.14, 95% CI: 0.07–0.49 and 0.08, 95%CI: 0.02–0.44, respectively). While a threshold effect was noted on average, TT increased 7 ng/dL for each additional 1000 steps taken daily (β-estimate: 0.007, 95% CI: 0.002–0.013).
Conclusions
Patients with the lowest daily step counts had higher odds of being hypogonadal. The current work supports a possible association between daily steps, total testosterone, and hypogonadism for men in the US.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33580402</pmid><doi>10.1007/s12020-021-02631-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3865-5988</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Diabetes Endocrinology Humanities and Social Sciences Hypogonadism Internal Medicine Medicine Medicine & Public Health multidisciplinary Original Original Article Physical activity Science Testosterone |
| title | Association of daily step count and serum testosterone among men in the United States |
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