CCL17-producing cDC2s are essential in end-stage lupus nephritis and averted by a parasitic infection

Lupus nephritis is a severe organ manifestation in systemic lupus erythematosus leading to kidney failure in a subset of patients. In lupus-prone mice, controlled infection with Plasmodium parasites protects against the progression of autoimmune pathology including lethal glomerulonephritis. Here, w...

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Veröffentlicht in:	The Journal of clinical investigation 2021-06, Vol.131 (11), p.1-15
Hauptverfasser:	Amo, Laura, Kole, Hemanta K, Scott, Bethany, Qi, Chen-Feng, Wu, Juan, Bolland, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Antigens Autoimmunity Biomedical research Blocking antibodies Bone marrow CCL17 protein Chemokine CCL17 - genetics Chemokine CCL17 - immunology Chemokines Cytokines Dendritic cells Dendritic Cells - immunology Development and progression Disease Models, Animal Experiments Glomerulonephritis Health aspects Hypoxia Infections Inflammation Kidney diseases Kidneys Lupus Lupus nephritis Lupus Nephritis - genetics Lupus Nephritis - immunology Lupus Nephritis - prevention & control Lymph nodes Malaria Malaria - genetics Malaria - immunology Malaria - pathology Mice Mice, Knockout Nephritis Parasites Parasitic diseases Pathology Physiological aspects Plasmodium Plasmodium yoelii - immunology Renal failure Rodents Systemic lupus erythematosus Vasculitis
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