In Vivo Proton MR Spectroscopy of Primary and Nodal Nasopharyngeal Carcinoma
The aim of this study was to determine the feasibility of performing in vivo proton ((1)H) MR spectroscopy of nasopharyngeal carcinoma (NPC) and to document the (1)H spectrum of this cancer. Twenty-seven patients with NPC lesions >1 cm(3) underwent localized (1)H MR spectroscopy performed at 1.5...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2004-03, Vol.25 (3), p.484-490 |
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| creator | King, Ann D Yeung, David K.W Ahuja, Anil T Leung, S.F Tse, Gary M.K van Hasselt, Andrew C |
| description | The aim of this study was to determine the feasibility of performing in vivo proton ((1)H) MR spectroscopy of nasopharyngeal carcinoma (NPC) and to document the (1)H spectrum of this cancer.
Twenty-seven patients with NPC lesions >1 cm(3) underwent localized (1)H MR spectroscopy performed at 1.5 T. Water-suppressed spectra from both primary tumors (nine cases) and metastatic nodes (18 cases) were obtained at TE 136 and 272. Spectra were analyzed in the time domain by using a nonlinear least squares fitting algorithm with incorporation of previous knowledge. Choline (Cho)/creatine (Cr) ratios for primary NPC and metastatic nodes were calculated and compared. Spectra from normal neck muscle of five volunteers were acquired as control data.
(1)H MR spectroscopy was successfully obtained in seven (78%) of nine primary tumors and 16 (89%) of 18 metastatic nodes. Intense lipid signals in the range of 0.89 to 2.02 ppm were observed in 95% of spectra at TE 136 and 91% of spectra at TE 272. At TE 136, Cho/Cr for metastatic nodes (5.3 +/- 1.6) was significantly higher than the ratio for primary (2.6 +/- 0.5) NPC lesions (P =.02). Cho/Cr ratios for NPC lesions were higher than those for normal neck muscles, for which values ranged from 0 to 0.97 and 0 to 1.1 at TE 136 and 272, respectively.
(1)H MR spectroscopy is a feasible technique for the evaluation of NPC tumors >1 cm(3). Cho/Cr ratios for the lesions were high compared with those for normal neck muscle. |
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Twenty-seven patients with NPC lesions >1 cm(3) underwent localized (1)H MR spectroscopy performed at 1.5 T. Water-suppressed spectra from both primary tumors (nine cases) and metastatic nodes (18 cases) were obtained at TE 136 and 272. Spectra were analyzed in the time domain by using a nonlinear least squares fitting algorithm with incorporation of previous knowledge. Choline (Cho)/creatine (Cr) ratios for primary NPC and metastatic nodes were calculated and compared. Spectra from normal neck muscle of five volunteers were acquired as control data.
(1)H MR spectroscopy was successfully obtained in seven (78%) of nine primary tumors and 16 (89%) of 18 metastatic nodes. Intense lipid signals in the range of 0.89 to 2.02 ppm were observed in 95% of spectra at TE 136 and 91% of spectra at TE 272. At TE 136, Cho/Cr for metastatic nodes (5.3 +/- 1.6) was significantly higher than the ratio for primary (2.6 +/- 0.5) NPC lesions (P =.02). Cho/Cr ratios for NPC lesions were higher than those for normal neck muscles, for which values ranged from 0 to 0.97 and 0 to 1.1 at TE 136 and 272, respectively.
(1)H MR spectroscopy is a feasible technique for the evaluation of NPC tumors >1 cm(3). Cho/Cr ratios for the lesions were high compared with those for normal neck muscle.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 15037477</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Adult ; Aged ; Algorithms ; Biological and medical sciences ; Choline - metabolism ; Creatine - metabolism ; Data Interpretation, Statistical ; Energy Metabolism - physiology ; Equipment Design ; Feasibility Studies ; Female ; Head and Neck ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Least-Squares Analysis ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Magnetic Resonance Imaging - instrumentation ; Magnetic Resonance Spectroscopy - instrumentation ; Male ; Medical sciences ; Middle Aged ; Nasopharyngeal Neoplasms - pathology ; Nasopharynx - pathology ; Neck Muscles - pathology ; Nervous system ; Nonlinear Dynamics ; Predictive Value of Tests ; Prospective Studies ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Reference Values</subject><ispartof>American journal of neuroradiology : AJNR, 2004-03, Vol.25 (3), p.484-490</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158563/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158563/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15592445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15037477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Ann D</creatorcontrib><creatorcontrib>Yeung, David K.W</creatorcontrib><creatorcontrib>Ahuja, Anil T</creatorcontrib><creatorcontrib>Leung, S.F</creatorcontrib><creatorcontrib>Tse, Gary M.K</creatorcontrib><creatorcontrib>van Hasselt, Andrew C</creatorcontrib><title>In Vivo Proton MR Spectroscopy of Primary and Nodal Nasopharyngeal Carcinoma</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>The aim of this study was to determine the feasibility of performing in vivo proton ((1)H) MR spectroscopy of nasopharyngeal carcinoma (NPC) and to document the (1)H spectrum of this cancer.
Twenty-seven patients with NPC lesions >1 cm(3) underwent localized (1)H MR spectroscopy performed at 1.5 T. Water-suppressed spectra from both primary tumors (nine cases) and metastatic nodes (18 cases) were obtained at TE 136 and 272. Spectra were analyzed in the time domain by using a nonlinear least squares fitting algorithm with incorporation of previous knowledge. Choline (Cho)/creatine (Cr) ratios for primary NPC and metastatic nodes were calculated and compared. Spectra from normal neck muscle of five volunteers were acquired as control data.
(1)H MR spectroscopy was successfully obtained in seven (78%) of nine primary tumors and 16 (89%) of 18 metastatic nodes. Intense lipid signals in the range of 0.89 to 2.02 ppm were observed in 95% of spectra at TE 136 and 91% of spectra at TE 272. At TE 136, Cho/Cr for metastatic nodes (5.3 +/- 1.6) was significantly higher than the ratio for primary (2.6 +/- 0.5) NPC lesions (P =.02). Cho/Cr ratios for NPC lesions were higher than those for normal neck muscles, for which values ranged from 0 to 0.97 and 0 to 1.1 at TE 136 and 272, respectively.
(1)H MR spectroscopy is a feasible technique for the evaluation of NPC tumors >1 cm(3). Cho/Cr ratios for the lesions were high compared with those for normal neck muscle.</description><subject>Adult</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Data Interpretation, Statistical</subject><subject>Energy Metabolism - physiology</subject><subject>Equipment Design</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Head and Neck</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Least-Squares Analysis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Magnetic Resonance Imaging - instrumentation</subject><subject>Magnetic Resonance Spectroscopy - instrumentation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharynx - pathology</subject><subject>Neck Muscles - pathology</subject><subject>Nervous system</subject><subject>Nonlinear Dynamics</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reference Values</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMlKxEAQhoMozri8guSit0Av6XT6IsjgBuOCG96aSi-TlqQ7pjMO8_YGHLdTUfV_fFXUVjLFghaZYOJ1O5kiLFhWYFROkr0Y3xBCTHCym0wwQ5TnnE-T-bVPX9xHSO_7MASf3jykj51RQx-iCt06DXZMXAv9OgWv09ugoUlvIYauHmd-YcZ2Br1yPrRwkOxYaKI53NT95Pni_Gl2lc3vLq9nZ_OspoQMGaHMcrDK4gK0KCqVVwVgi0UpFCNcMc1sIbTCVa4x0xUTJSs0QQirEhtm6X5y-uXtllVrtDJ-6KGR3dehMoCT_xPvarkIH7LEbFTRUXCyEfThfWniIFsXlWka8CYso-SY54QiPoJHfzf9rPh-4AgcbwCIChrbg1cu_uGYIHnOfrnaLeqV642MLTTNqMVytVoRJqnMy5x-AjV9iOc</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>King, Ann D</creator><creator>Yeung, David K.W</creator><creator>Ahuja, Anil T</creator><creator>Leung, S.F</creator><creator>Tse, Gary M.K</creator><creator>van Hasselt, Andrew C</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040301</creationdate><title>In Vivo Proton MR Spectroscopy of Primary and Nodal Nasopharyngeal Carcinoma</title><author>King, Ann D ; Yeung, David K.W ; Ahuja, Anil T ; Leung, S.F ; Tse, Gary M.K ; van Hasselt, Andrew C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h322t-235f7afcf16ad96bc4b6a1f1989c527c5d5f69dc1b4d15db59856d2001c81e5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Data Interpretation, Statistical</topic><topic>Energy Metabolism - physiology</topic><topic>Equipment Design</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Head and Neck</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Least-Squares Analysis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Magnetic Resonance Imaging - instrumentation</topic><topic>Magnetic Resonance Spectroscopy - instrumentation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharynx - pathology</topic><topic>Neck Muscles - pathology</topic><topic>Nervous system</topic><topic>Nonlinear Dynamics</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Ann D</creatorcontrib><creatorcontrib>Yeung, David K.W</creatorcontrib><creatorcontrib>Ahuja, Anil T</creatorcontrib><creatorcontrib>Leung, S.F</creatorcontrib><creatorcontrib>Tse, Gary M.K</creatorcontrib><creatorcontrib>van Hasselt, Andrew C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Ann D</au><au>Yeung, David K.W</au><au>Ahuja, Anil T</au><au>Leung, S.F</au><au>Tse, Gary M.K</au><au>van Hasselt, Andrew C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Proton MR Spectroscopy of Primary and Nodal Nasopharyngeal Carcinoma</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>25</volume><issue>3</issue><spage>484</spage><epage>490</epage><pages>484-490</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>The aim of this study was to determine the feasibility of performing in vivo proton ((1)H) MR spectroscopy of nasopharyngeal carcinoma (NPC) and to document the (1)H spectrum of this cancer.
Twenty-seven patients with NPC lesions >1 cm(3) underwent localized (1)H MR spectroscopy performed at 1.5 T. Water-suppressed spectra from both primary tumors (nine cases) and metastatic nodes (18 cases) were obtained at TE 136 and 272. Spectra were analyzed in the time domain by using a nonlinear least squares fitting algorithm with incorporation of previous knowledge. Choline (Cho)/creatine (Cr) ratios for primary NPC and metastatic nodes were calculated and compared. Spectra from normal neck muscle of five volunteers were acquired as control data.
(1)H MR spectroscopy was successfully obtained in seven (78%) of nine primary tumors and 16 (89%) of 18 metastatic nodes. Intense lipid signals in the range of 0.89 to 2.02 ppm were observed in 95% of spectra at TE 136 and 91% of spectra at TE 272. At TE 136, Cho/Cr for metastatic nodes (5.3 +/- 1.6) was significantly higher than the ratio for primary (2.6 +/- 0.5) NPC lesions (P =.02). Cho/Cr ratios for NPC lesions were higher than those for normal neck muscles, for which values ranged from 0 to 0.97 and 0 to 1.1 at TE 136 and 272, respectively.
(1)H MR spectroscopy is a feasible technique for the evaluation of NPC tumors >1 cm(3). Cho/Cr ratios for the lesions were high compared with those for normal neck muscle.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>15037477</pmid><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Algorithms Biological and medical sciences Choline - metabolism Creatine - metabolism Data Interpretation, Statistical Energy Metabolism - physiology Equipment Design Feasibility Studies Female Head and Neck Humans Investigative techniques, diagnostic techniques (general aspects) Least-Squares Analysis Lymph Nodes - pathology Lymphatic Metastasis - pathology Magnetic Resonance Imaging - instrumentation Magnetic Resonance Spectroscopy - instrumentation Male Medical sciences Middle Aged Nasopharyngeal Neoplasms - pathology Nasopharynx - pathology Neck Muscles - pathology Nervous system Nonlinear Dynamics Predictive Value of Tests Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values |
| title | In Vivo Proton MR Spectroscopy of Primary and Nodal Nasopharyngeal Carcinoma |
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