Radical cascade synthesis of azoles via tandem hydrogen atom transfer

A radical cascade strategy for the modular synthesis of five-membered heteroarenes ( oxazoles, imidazoles) from feedstock reagents ( alcohols, amines, nitriles) has been developed. This double C-H oxidation is enabled by generated imidate and acyloxy radicals, which afford regio- and chemo-selective...

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Veröffentlicht in:	Chemical science (Cambridge) 2020-01, Vol.11 (9), p.2479-2486
Hauptverfasser:	Chen, Andrew D, Herbort, James H, Wappes, Ethan A, Nakafuku, Kohki M, Mustafa, Darsheed N, Nagib, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Amines Chemical synthesis Chemistry Heterocyclic compounds Nitriles Oxidation Reagents Selectivity
Online-Zugang:	Volltext
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