Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma

Abstract Background For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) f...

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Veröffentlicht in:	Neuro-oncology advances 2021-01, Vol.3 (1), p.vdab058-vdab058
Hauptverfasser:	Khasraw, Mustafa, Weller, Michael, Lorente, David, Kolibaba, Kathryn, Lee, Chee Khoon, Gedye, Craig, I. de La Fuente, Macarena, Vicente, David, Reardon, David A, Gan, Hui K, Scott, Andrew M, Dussault, Isabelle, Helwig, Christoph, Ojalvo, Laureen S, Gourmelon, Carole, Groves, Morris
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical Investigations
Online-Zugang:	Volltext
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