The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma
Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of th...
Gespeichert in:
| Veröffentlicht in: | Cancers 2021-05, Vol.13 (10), p.2398 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 2398 |
| container_title | Cancers |
| container_volume | 13 |
| creator | Serenari, Matteo Prosperi, Enrico Allard, Marc-Antoine Paterno, Michele Golse, Nicolas Laurenzi, Andrea Adam, René Ravaioli, Matteo Cherqui, Daniel Cescon, Matteo |
| description | Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of the study was to analyze the impact of HR on post-LT complications. A Comprehensive Complication Index ≥ 29.6 was chosen as cutoff. The secondary outcome was HCC-related death by means of competing-risk regression analysis. In the study period, 140 patients were included. Patients were transplanted in a median of 23 months after HR (IQR 14–41). Among all the features analyzed regarding the prior HR, only time interval between HR and SLT (time HR-SLT) was an independent predictor of severe complications after LT (OR = 0.98, p < 0.001). According to fractional polynomial regression, the probability of severe complications increased up to 15 months after HR (43%), then slowly decreased over time (OR = 0.88, p < 0.001). There was no significant association between HCC-related death and time HR-SLT at the multivariable competing risks regression model (SHR, 1.06; 95% CI: 0.69–1.62, p = 0.796). This study showed that time HR-SLT was key in predicting complications after LT, without affecting HCC-related death. |
| doi_str_mv | 10.3390/cancers13102398 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8156967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2532426417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-f6685dfe221f8ca62045f233a79b53b88d9a3ed61985d9438a07c6aaf1db94253</originalsourceid><addsrcrecordid>eNpdkU9r3DAQxUVpaUKac66CXnrZRH9sWboUytImgYWUsjmbsTzuKtiSK8kb-iHynaPthtJGCCTx3vw0jyHkgrNLKQ27suAtxsQlZ0Ia_YacCtaIlVKmevvP_YScp_TAypKSN6p5T05kxZSsGT8lT9sd0ttpBptpGOjWTeXpM8Y9jLTD_Ijo6Q3OkJ2lPzChzS54Cr6nG7fHSLcRfJpH8Bn-KGWvR-edLfV3S7ahAJ2n34uKPif66PLuCAwWx3EZIdI1ROt8mOADeTfAmPD85Twj99--btc3q83d9e36y2ZlS868GpTSdT-gEHzQFpRgVT0IKaExXS07rXsDEnvFTbGZSmpgjVUAA-87U4lanpHPR-68dBP2tnQWYWzn6CaIv9sArv1f8W7X_gz7VvNaGdUUwKcXQAy_Fky5nVw65AGPYUlt-UNVWmiti_XjK-tDWKIv8Q4uUQlV8QPw6uiyMaQUcfjbDGftYdrtq2nLZ-M6n5o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2532426417</pqid></control><display><type>article</type><title>The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Serenari, Matteo ; Prosperi, Enrico ; Allard, Marc-Antoine ; Paterno, Michele ; Golse, Nicolas ; Laurenzi, Andrea ; Adam, René ; Ravaioli, Matteo ; Cherqui, Daniel ; Cescon, Matteo</creator><creatorcontrib>Serenari, Matteo ; Prosperi, Enrico ; Allard, Marc-Antoine ; Paterno, Michele ; Golse, Nicolas ; Laurenzi, Andrea ; Adam, René ; Ravaioli, Matteo ; Cherqui, Daniel ; Cescon, Matteo</creatorcontrib><description>Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of the study was to analyze the impact of HR on post-LT complications. A Comprehensive Complication Index ≥ 29.6 was chosen as cutoff. The secondary outcome was HCC-related death by means of competing-risk regression analysis. In the study period, 140 patients were included. Patients were transplanted in a median of 23 months after HR (IQR 14–41). Among all the features analyzed regarding the prior HR, only time interval between HR and SLT (time HR-SLT) was an independent predictor of severe complications after LT (OR = 0.98, p < 0.001). According to fractional polynomial regression, the probability of severe complications increased up to 15 months after HR (43%), then slowly decreased over time (OR = 0.88, p < 0.001). There was no significant association between HCC-related death and time HR-SLT at the multivariable competing risks regression model (SHR, 1.06; 95% CI: 0.69–1.62, p = 0.796). This study showed that time HR-SLT was key in predicting complications after LT, without affecting HCC-related death.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13102398</identifier><identifier>PMID: 34063501</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Blood transfusions ; Death ; Hemorrhage ; Hepatocellular carcinoma ; Liver ; Liver diseases ; Liver transplantation ; Patients ; Regression analysis ; Surgery ; Surgical outcomes ; Survival analysis ; Transplants & implants ; Variables</subject><ispartof>Cancers, 2021-05, Vol.13 (10), p.2398</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-f6685dfe221f8ca62045f233a79b53b88d9a3ed61985d9438a07c6aaf1db94253</citedby><cites>FETCH-LOGICAL-c398t-f6685dfe221f8ca62045f233a79b53b88d9a3ed61985d9438a07c6aaf1db94253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156967/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156967/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Serenari, Matteo</creatorcontrib><creatorcontrib>Prosperi, Enrico</creatorcontrib><creatorcontrib>Allard, Marc-Antoine</creatorcontrib><creatorcontrib>Paterno, Michele</creatorcontrib><creatorcontrib>Golse, Nicolas</creatorcontrib><creatorcontrib>Laurenzi, Andrea</creatorcontrib><creatorcontrib>Adam, René</creatorcontrib><creatorcontrib>Ravaioli, Matteo</creatorcontrib><creatorcontrib>Cherqui, Daniel</creatorcontrib><creatorcontrib>Cescon, Matteo</creatorcontrib><title>The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma</title><title>Cancers</title><description>Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of the study was to analyze the impact of HR on post-LT complications. A Comprehensive Complication Index ≥ 29.6 was chosen as cutoff. The secondary outcome was HCC-related death by means of competing-risk regression analysis. In the study period, 140 patients were included. Patients were transplanted in a median of 23 months after HR (IQR 14–41). Among all the features analyzed regarding the prior HR, only time interval between HR and SLT (time HR-SLT) was an independent predictor of severe complications after LT (OR = 0.98, p < 0.001). According to fractional polynomial regression, the probability of severe complications increased up to 15 months after HR (43%), then slowly decreased over time (OR = 0.88, p < 0.001). There was no significant association between HCC-related death and time HR-SLT at the multivariable competing risks regression model (SHR, 1.06; 95% CI: 0.69–1.62, p = 0.796). This study showed that time HR-SLT was key in predicting complications after LT, without affecting HCC-related death.</description><subject>Blood transfusions</subject><subject>Death</subject><subject>Hemorrhage</subject><subject>Hepatocellular carcinoma</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver transplantation</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Survival analysis</subject><subject>Transplants & implants</subject><subject>Variables</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU9r3DAQxUVpaUKac66CXnrZRH9sWboUytImgYWUsjmbsTzuKtiSK8kb-iHynaPthtJGCCTx3vw0jyHkgrNLKQ27suAtxsQlZ0Ia_YacCtaIlVKmevvP_YScp_TAypKSN6p5T05kxZSsGT8lT9sd0ttpBptpGOjWTeXpM8Y9jLTD_Ijo6Q3OkJ2lPzChzS54Cr6nG7fHSLcRfJpH8Bn-KGWvR-edLfV3S7ahAJ2n34uKPif66PLuCAwWx3EZIdI1ROt8mOADeTfAmPD85Twj99--btc3q83d9e36y2ZlS868GpTSdT-gEHzQFpRgVT0IKaExXS07rXsDEnvFTbGZSmpgjVUAA-87U4lanpHPR-68dBP2tnQWYWzn6CaIv9sArv1f8W7X_gz7VvNaGdUUwKcXQAy_Fky5nVw65AGPYUlt-UNVWmiti_XjK-tDWKIv8Q4uUQlV8QPw6uiyMaQUcfjbDGftYdrtq2nLZ-M6n5o</recordid><startdate>20210515</startdate><enddate>20210515</enddate><creator>Serenari, Matteo</creator><creator>Prosperi, Enrico</creator><creator>Allard, Marc-Antoine</creator><creator>Paterno, Michele</creator><creator>Golse, Nicolas</creator><creator>Laurenzi, Andrea</creator><creator>Adam, René</creator><creator>Ravaioli, Matteo</creator><creator>Cherqui, Daniel</creator><creator>Cescon, Matteo</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210515</creationdate><title>The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma</title><author>Serenari, Matteo ; Prosperi, Enrico ; Allard, Marc-Antoine ; Paterno, Michele ; Golse, Nicolas ; Laurenzi, Andrea ; Adam, René ; Ravaioli, Matteo ; Cherqui, Daniel ; Cescon, Matteo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-f6685dfe221f8ca62045f233a79b53b88d9a3ed61985d9438a07c6aaf1db94253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Blood transfusions</topic><topic>Death</topic><topic>Hemorrhage</topic><topic>Hepatocellular carcinoma</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Liver transplantation</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Survival analysis</topic><topic>Transplants & implants</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serenari, Matteo</creatorcontrib><creatorcontrib>Prosperi, Enrico</creatorcontrib><creatorcontrib>Allard, Marc-Antoine</creatorcontrib><creatorcontrib>Paterno, Michele</creatorcontrib><creatorcontrib>Golse, Nicolas</creatorcontrib><creatorcontrib>Laurenzi, Andrea</creatorcontrib><creatorcontrib>Adam, René</creatorcontrib><creatorcontrib>Ravaioli, Matteo</creatorcontrib><creatorcontrib>Cherqui, Daniel</creatorcontrib><creatorcontrib>Cescon, Matteo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serenari, Matteo</au><au>Prosperi, Enrico</au><au>Allard, Marc-Antoine</au><au>Paterno, Michele</au><au>Golse, Nicolas</au><au>Laurenzi, Andrea</au><au>Adam, René</au><au>Ravaioli, Matteo</au><au>Cherqui, Daniel</au><au>Cescon, Matteo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma</atitle><jtitle>Cancers</jtitle><date>2021-05-15</date><risdate>2021</risdate><volume>13</volume><issue>10</issue><spage>2398</spage><pages>2398-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of the study was to analyze the impact of HR on post-LT complications. A Comprehensive Complication Index ≥ 29.6 was chosen as cutoff. The secondary outcome was HCC-related death by means of competing-risk regression analysis. In the study period, 140 patients were included. Patients were transplanted in a median of 23 months after HR (IQR 14–41). Among all the features analyzed regarding the prior HR, only time interval between HR and SLT (time HR-SLT) was an independent predictor of severe complications after LT (OR = 0.98, p < 0.001). According to fractional polynomial regression, the probability of severe complications increased up to 15 months after HR (43%), then slowly decreased over time (OR = 0.88, p < 0.001). There was no significant association between HCC-related death and time HR-SLT at the multivariable competing risks regression model (SHR, 1.06; 95% CI: 0.69–1.62, p = 0.796). This study showed that time HR-SLT was key in predicting complications after LT, without affecting HCC-related death.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34063501</pmid><doi>10.3390/cancers13102398</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2021-05, Vol.13 (10), p.2398 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8156967 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Blood transfusions Death Hemorrhage Hepatocellular carcinoma Liver Liver diseases Liver transplantation Patients Regression analysis Surgery Surgical outcomes Survival analysis Transplants & implants Variables |
| title | The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T20%3A51%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Impact%20of%20Time%20Interval%20between%20Hepatic%20Resection%20and%20Liver%20Transplantation%20on%20Clinical%20Outcome%20in%20Patients%20with%20Hepatocellular%20Carcinoma&rft.jtitle=Cancers&rft.au=Serenari,%20Matteo&rft.date=2021-05-15&rft.volume=13&rft.issue=10&rft.spage=2398&rft.pages=2398-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers13102398&rft_dat=%3Cproquest_pubme%3E2532426417%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2532426417&rft_id=info:pmid/34063501&rfr_iscdi=true |