Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients
The effect of perioperative sarcopenic changes on prognosis remains unclear. We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abd...
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| Veröffentlicht in: | Cancers 2021-05, Vol.13 (10), p.2410 |
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| creator | Lee, Chungyeop Park, In-Ja Kim, Kyung-Won Shin, Yongbin Lim, Seok-Byung Kim, Chan-Wook Yoon, Yong-Sik Lee, Jong-Lyul Yu, Chang-Sik Kim, Jin-Cheon |
| description | The effect of perioperative sarcopenic changes on prognosis remains unclear. We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abdominopelvic computed tomography (CT) using Asan-J software. Patients underwent CT scans preoperatively, as well as at 6 months–1 year and 2–3 years postoperatively. The primary outcome was the association between perioperative sarcopenic changes and survival. According to sarcopenic criteria, 1155 (49.5%), 890 (38.2%), and 893 (38.3%) patients had sarcopenia preoperatively, 6 months–1 year, and 2–3 years postoperatively, respectively. The 5-year overall survival (OS) (95.8% vs. 92.1%, hazard ratio (HR) = 2.234, p < 0.001) and 5-year recurrence-free survival (RFS) (93.2% vs. 86.2%, HR = 2.251, p < 0.001) rates were significantly lower in patients with preoperative sarcopenia. Both OS and RFS were lower in patients with persistent sarcopenia 2–3 years postoperatively than in those who recovered (OS: 96.2% vs. 90.2%, p = 0.001; RFS: 91.1% vs. 83.9%, p = 0.002). In multivariate analysis, postoperative sarcopenia was confirmed as an independent factor associated with decreased OS and RFS. Pre- and postoperative sarcopenia and changes in the condition during surveillance were associated with oncological outcomes. |
| doi_str_mv | 10.3390/cancers13102410 |
| format | Article |
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We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abdominopelvic computed tomography (CT) using Asan-J software. Patients underwent CT scans preoperatively, as well as at 6 months–1 year and 2–3 years postoperatively. The primary outcome was the association between perioperative sarcopenic changes and survival. According to sarcopenic criteria, 1155 (49.5%), 890 (38.2%), and 893 (38.3%) patients had sarcopenia preoperatively, 6 months–1 year, and 2–3 years postoperatively, respectively. The 5-year overall survival (OS) (95.8% vs. 92.1%, hazard ratio (HR) = 2.234, p < 0.001) and 5-year recurrence-free survival (RFS) (93.2% vs. 86.2%, HR = 2.251, p < 0.001) rates were significantly lower in patients with preoperative sarcopenia. Both OS and RFS were lower in patients with persistent sarcopenia 2–3 years postoperatively than in those who recovered (OS: 96.2% vs. 90.2%, p = 0.001; RFS: 91.1% vs. 83.9%, p = 0.002). In multivariate analysis, postoperative sarcopenia was confirmed as an independent factor associated with decreased OS and RFS. Pre- and postoperative sarcopenia and changes in the condition during surveillance were associated with oncological outcomes.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13102410</identifier><identifier>PMID: 34067568</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Body composition ; Cancer ; Chemotherapy ; Colorectal cancer ; Colorectal carcinoma ; Computed tomography ; Magnetic resonance imaging ; Males ; Medical imaging ; Metastases ; Metastasis ; Multivariate analysis ; Musculoskeletal system ; Sarcopenia ; Surgery ; Surveillance ; Survival</subject><ispartof>Cancers, 2021-05, Vol.13 (10), p.2410</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-892a82e10914b0f3026f41a98e75387078710a93e28667a69d6361f049ca5dd23</citedby><cites>FETCH-LOGICAL-c398t-892a82e10914b0f3026f41a98e75387078710a93e28667a69d6361f049ca5dd23</cites><orcidid>0000-0001-9401-9981 ; 0000-0001-5355-3969 ; 0000-0002-1532-5970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156120/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156120/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids></links><search><creatorcontrib>Lee, Chungyeop</creatorcontrib><creatorcontrib>Park, In-Ja</creatorcontrib><creatorcontrib>Kim, Kyung-Won</creatorcontrib><creatorcontrib>Shin, Yongbin</creatorcontrib><creatorcontrib>Lim, Seok-Byung</creatorcontrib><creatorcontrib>Kim, Chan-Wook</creatorcontrib><creatorcontrib>Yoon, Yong-Sik</creatorcontrib><creatorcontrib>Lee, Jong-Lyul</creatorcontrib><creatorcontrib>Yu, Chang-Sik</creatorcontrib><creatorcontrib>Kim, Jin-Cheon</creatorcontrib><title>Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients</title><title>Cancers</title><description>The effect of perioperative sarcopenic changes on prognosis remains unclear. We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abdominopelvic computed tomography (CT) using Asan-J software. Patients underwent CT scans preoperatively, as well as at 6 months–1 year and 2–3 years postoperatively. The primary outcome was the association between perioperative sarcopenic changes and survival. According to sarcopenic criteria, 1155 (49.5%), 890 (38.2%), and 893 (38.3%) patients had sarcopenia preoperatively, 6 months–1 year, and 2–3 years postoperatively, respectively. The 5-year overall survival (OS) (95.8% vs. 92.1%, hazard ratio (HR) = 2.234, p < 0.001) and 5-year recurrence-free survival (RFS) (93.2% vs. 86.2%, HR = 2.251, p < 0.001) rates were significantly lower in patients with preoperative sarcopenia. Both OS and RFS were lower in patients with persistent sarcopenia 2–3 years postoperatively than in those who recovered (OS: 96.2% vs. 90.2%, p = 0.001; RFS: 91.1% vs. 83.9%, p = 0.002). In multivariate analysis, postoperative sarcopenia was confirmed as an independent factor associated with decreased OS and RFS. Pre- and postoperative sarcopenia and changes in the condition during surveillance were associated with oncological outcomes.</description><subject>Body composition</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Computed tomography</subject><subject>Magnetic resonance imaging</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Musculoskeletal system</subject><subject>Sarcopenia</subject><subject>Surgery</subject><subject>Surveillance</subject><subject>Survival</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUlrHDEQhUWIic3YZ18FueTStrbWcgmEJl5gkhhsn0VZUz1u0yNNpO4B_3trYhMS61JC76tXJR4hp5ydSenYeYAYMBcuOROKsw_kSDAjGq2d-vjP_ZCclPLE6pGSG20-kUOpmDattkekXMd-nLEa0dTTm1SmtMUM07BD2j1CXGOhQ6S3kEMV4gA0RbpMcd3cYd7Q2znvhh2Me-Znis0PnKBMtT3QLo0pY5iq2P1ZlN7Ud4xTOSYHPYwFT97qgtxffL_rrprlr8vr7tuyCdLZqbFOgBXImePqgfWSCd0rDs6iaaU1zFjDGTiJwmptQLuVlpr3TLkA7Wol5IJ8ffXdzg8bXIU6O8Pot3nYQH72CQb_vxKHR79OO295q7lg1eDLm0FOv2csk98MJeA4QsQ0Fy9aqZVhVsmKfn6HPqU5x_q9PSWU0DWmSp2_UiGnUjL2f5fhzO8z9e8ylS_oyZRS</recordid><startdate>20210517</startdate><enddate>20210517</enddate><creator>Lee, Chungyeop</creator><creator>Park, In-Ja</creator><creator>Kim, Kyung-Won</creator><creator>Shin, Yongbin</creator><creator>Lim, Seok-Byung</creator><creator>Kim, Chan-Wook</creator><creator>Yoon, Yong-Sik</creator><creator>Lee, Jong-Lyul</creator><creator>Yu, Chang-Sik</creator><creator>Kim, Jin-Cheon</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9401-9981</orcidid><orcidid>https://orcid.org/0000-0001-5355-3969</orcidid><orcidid>https://orcid.org/0000-0002-1532-5970</orcidid></search><sort><creationdate>20210517</creationdate><title>Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients</title><author>Lee, Chungyeop ; Park, In-Ja ; Kim, Kyung-Won ; Shin, Yongbin ; Lim, Seok-Byung ; Kim, Chan-Wook ; Yoon, Yong-Sik ; Lee, Jong-Lyul ; Yu, Chang-Sik ; Kim, Jin-Cheon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-892a82e10914b0f3026f41a98e75387078710a93e28667a69d6361f049ca5dd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body composition</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Computed tomography</topic><topic>Magnetic resonance imaging</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Musculoskeletal system</topic><topic>Sarcopenia</topic><topic>Surgery</topic><topic>Surveillance</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chungyeop</creatorcontrib><creatorcontrib>Park, In-Ja</creatorcontrib><creatorcontrib>Kim, Kyung-Won</creatorcontrib><creatorcontrib>Shin, Yongbin</creatorcontrib><creatorcontrib>Lim, Seok-Byung</creatorcontrib><creatorcontrib>Kim, Chan-Wook</creatorcontrib><creatorcontrib>Yoon, Yong-Sik</creatorcontrib><creatorcontrib>Lee, Jong-Lyul</creatorcontrib><creatorcontrib>Yu, Chang-Sik</creatorcontrib><creatorcontrib>Kim, Jin-Cheon</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chungyeop</au><au>Park, In-Ja</au><au>Kim, Kyung-Won</au><au>Shin, Yongbin</au><au>Lim, Seok-Byung</au><au>Kim, Chan-Wook</au><au>Yoon, Yong-Sik</au><au>Lee, Jong-Lyul</au><au>Yu, Chang-Sik</au><au>Kim, Jin-Cheon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients</atitle><jtitle>Cancers</jtitle><date>2021-05-17</date><risdate>2021</risdate><volume>13</volume><issue>10</issue><spage>2410</spage><pages>2410-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The effect of perioperative sarcopenic changes on prognosis remains unclear. We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abdominopelvic computed tomography (CT) using Asan-J software. Patients underwent CT scans preoperatively, as well as at 6 months–1 year and 2–3 years postoperatively. The primary outcome was the association between perioperative sarcopenic changes and survival. According to sarcopenic criteria, 1155 (49.5%), 890 (38.2%), and 893 (38.3%) patients had sarcopenia preoperatively, 6 months–1 year, and 2–3 years postoperatively, respectively. The 5-year overall survival (OS) (95.8% vs. 92.1%, hazard ratio (HR) = 2.234, p < 0.001) and 5-year recurrence-free survival (RFS) (93.2% vs. 86.2%, HR = 2.251, p < 0.001) rates were significantly lower in patients with preoperative sarcopenia. Both OS and RFS were lower in patients with persistent sarcopenia 2–3 years postoperatively than in those who recovered (OS: 96.2% vs. 90.2%, p = 0.001; RFS: 91.1% vs. 83.9%, p = 0.002). In multivariate analysis, postoperative sarcopenia was confirmed as an independent factor associated with decreased OS and RFS. Pre- and postoperative sarcopenia and changes in the condition during surveillance were associated with oncological outcomes.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34067568</pmid><doi>10.3390/cancers13102410</doi><orcidid>https://orcid.org/0000-0001-9401-9981</orcidid><orcidid>https://orcid.org/0000-0001-5355-3969</orcidid><orcidid>https://orcid.org/0000-0002-1532-5970</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Body composition Cancer Chemotherapy Colorectal cancer Colorectal carcinoma Computed tomography Magnetic resonance imaging Males Medical imaging Metastases Metastasis Multivariate analysis Musculoskeletal system Sarcopenia Surgery Surveillance Survival |
| title | Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients |
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