Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma
Flavonoids as the largest group of natural phytochemical compounds have received significant attention, as demonstrated by clinical trials, due to their chemotherapeutic and/or pharmacological effects against non-small-cell lung cancer (NSCLC) and asthma. ( ), known as one of the most popular medici...
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| Veröffentlicht in: | International journal of environmental research and public health 2021-05, Vol.18 (10), p.5243 |
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| creator | Alsharairi, Naser A |
| description | Flavonoids as the largest group of natural phytochemical compounds have received significant attention, as demonstrated by clinical trials, due to their chemotherapeutic and/or pharmacological effects against non-small-cell lung cancer (NSCLC) and asthma.
(
), known as one of the most popular medicinal plants and used in several countries, contains natural active flavone constituents, with the major compounds of the roots being baicalein, baicalin, wogonin, wogonoside and oroxylin A.
and their compounds are proven to have inhibitory effects on NSCLC cells when used at different concentrations. However, the exact mechanisms by which these compounds exert their therapeutic effects against asthma remain unexplored. Indeed, the mechanisms by which
and its flavone compounds exert a protective effect against nicotine-induced NSCLC and asthma are not yet fully understood. Therefore, this review explores the mechanisms involved in the therapeutic potential of flavone-rich extracts from
in nicotine-induced NSCLC and asthma. |
| doi_str_mv | 10.3390/ijerph18105243 |
| format | Article |
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(
), known as one of the most popular medicinal plants and used in several countries, contains natural active flavone constituents, with the major compounds of the roots being baicalein, baicalin, wogonin, wogonoside and oroxylin A.
and their compounds are proven to have inhibitory effects on NSCLC cells when used at different concentrations. However, the exact mechanisms by which these compounds exert their therapeutic effects against asthma remain unexplored. Indeed, the mechanisms by which
and its flavone compounds exert a protective effect against nicotine-induced NSCLC and asthma are not yet fully understood. Therefore, this review explores the mechanisms involved in the therapeutic potential of flavone-rich extracts from
in nicotine-induced NSCLC and asthma.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph18105243</identifier><identifier>PMID: 34069141</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antigens ; Asthma ; Asthma - chemically induced ; Asthma - drug therapy ; Baicalin ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Cell cycle ; Cell division ; Chemical compounds ; Chemotherapy ; Clinical trials ; Cytotoxicity ; Flavanones ; Flavones - therapeutic use ; Flavonoids ; Growth factors ; Herbal medicine ; Humans ; Immunotherapy ; Kinases ; Lung cancer ; Lung Neoplasms - drug therapy ; Lymphocytes ; Medicinal plants ; Monoclonal antibodies ; Mortality ; Nicotine ; Non-small cell lung carcinoma ; Pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Proteins ; Review ; Scutellaria baicalensis ; Smoking ; Tumor necrosis factor-TNF</subject><ispartof>International journal of environmental research and public health, 2021-05, Vol.18 (10), p.5243</ispartof><rights>2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the author. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-add0ac58070a4daa4aa5210c9d39375cd77b0e5efbf3f015b534664e06bd916f3</citedby><cites>FETCH-LOGICAL-c418t-add0ac58070a4daa4aa5210c9d39375cd77b0e5efbf3f015b534664e06bd916f3</cites><orcidid>0000-0003-0619-4136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155851/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155851/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34069141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alsharairi, Naser A</creatorcontrib><title>Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Flavonoids as the largest group of natural phytochemical compounds have received significant attention, as demonstrated by clinical trials, due to their chemotherapeutic and/or pharmacological effects against non-small-cell lung cancer (NSCLC) and asthma.
(
), known as one of the most popular medicinal plants and used in several countries, contains natural active flavone constituents, with the major compounds of the roots being baicalein, baicalin, wogonin, wogonoside and oroxylin A.
and their compounds are proven to have inhibitory effects on NSCLC cells when used at different concentrations. However, the exact mechanisms by which these compounds exert their therapeutic effects against asthma remain unexplored. Indeed, the mechanisms by which
and its flavone compounds exert a protective effect against nicotine-induced NSCLC and asthma are not yet fully understood. Therefore, this review explores the mechanisms involved in the therapeutic potential of flavone-rich extracts from
in nicotine-induced NSCLC and asthma.</description><subject>Antigens</subject><subject>Asthma</subject><subject>Asthma - chemically induced</subject><subject>Asthma - drug therapy</subject><subject>Baicalin</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Chemical compounds</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Cytotoxicity</subject><subject>Flavanones</subject><subject>Flavones - therapeutic use</subject><subject>Flavonoids</subject><subject>Growth factors</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lymphocytes</subject><subject>Medicinal plants</subject><subject>Monoclonal antibodies</subject><subject>Mortality</subject><subject>Nicotine</subject><subject>Non-small cell lung carcinoma</subject><subject>Pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Proteins</subject><subject>Review</subject><subject>Scutellaria baicalensis</subject><subject>Smoking</subject><subject>Tumor necrosis factor-TNF</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkU1v1DAQhiNERUvhyhFZ4pxir-18XJCqlEKl7Rapyzma2JONV4m9-KMS_4cfimlL1Z5mpHn8zjt-i-IDo2ect_Sz2aM_TKxhVK4Ef1WcsKqipagoe_2sPy7ehrCnlDeiat8Ux1zQqmWCnRR_blWKOM_gDZABjIIZbTCBgNVkO6HxZAMxeZjJ5Qx3ziLp3HJwyerMBPLDRbTR5PE1aqOMzd2FT7tARudJnJBsPUJcMkTcSDZGuWgslldWJ4WabJwtbxeY57LLLsg62R3pwCr09w7OQ5wWeFccjTAHfP9YT4ufl1-33fdyffPtqjtfl0qwJpagNQUlG1pTEBpAAMgVo6rVvOW1VLquB4oSx2HkI2VykFxUlUBaDbpl1chPiy8Puoc0LKhVNp0P7w_eLOB_9w5M_3JizdTv3F3fMCkbybLAp0cB734lDLHfu-Tzn4R-JflKUtrWMlNnD5TyLgSP49MGRvt_qfYvU80PPj739YT_j5H_BZfmomU</recordid><startdate>20210514</startdate><enddate>20210514</enddate><creator>Alsharairi, Naser A</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0619-4136</orcidid></search><sort><creationdate>20210514</creationdate><title>Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma</title><author>Alsharairi, Naser A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-add0ac58070a4daa4aa5210c9d39375cd77b0e5efbf3f015b534664e06bd916f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antigens</topic><topic>Asthma</topic><topic>Asthma - chemically induced</topic><topic>Asthma - drug therapy</topic><topic>Baicalin</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Chemical compounds</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Cytotoxicity</topic><topic>Flavanones</topic><topic>Flavones - therapeutic use</topic><topic>Flavonoids</topic><topic>Growth factors</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lymphocytes</topic><topic>Medicinal plants</topic><topic>Monoclonal antibodies</topic><topic>Mortality</topic><topic>Nicotine</topic><topic>Non-small cell lung carcinoma</topic><topic>Pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Proteins</topic><topic>Review</topic><topic>Scutellaria baicalensis</topic><topic>Smoking</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alsharairi, Naser A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alsharairi, Naser A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2021-05-14</date><risdate>2021</risdate><volume>18</volume><issue>10</issue><spage>5243</spage><pages>5243-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Flavonoids as the largest group of natural phytochemical compounds have received significant attention, as demonstrated by clinical trials, due to their chemotherapeutic and/or pharmacological effects against non-small-cell lung cancer (NSCLC) and asthma.
(
), known as one of the most popular medicinal plants and used in several countries, contains natural active flavone constituents, with the major compounds of the roots being baicalein, baicalin, wogonin, wogonoside and oroxylin A.
and their compounds are proven to have inhibitory effects on NSCLC cells when used at different concentrations. However, the exact mechanisms by which these compounds exert their therapeutic effects against asthma remain unexplored. Indeed, the mechanisms by which
and its flavone compounds exert a protective effect against nicotine-induced NSCLC and asthma are not yet fully understood. Therefore, this review explores the mechanisms involved in the therapeutic potential of flavone-rich extracts from
in nicotine-induced NSCLC and asthma.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34069141</pmid><doi>10.3390/ijerph18105243</doi><orcidid>https://orcid.org/0000-0003-0619-4136</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antigens Asthma Asthma - chemically induced Asthma - drug therapy Baicalin Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Cell cycle Cell division Chemical compounds Chemotherapy Clinical trials Cytotoxicity Flavanones Flavones - therapeutic use Flavonoids Growth factors Herbal medicine Humans Immunotherapy Kinases Lung cancer Lung Neoplasms - drug therapy Lymphocytes Medicinal plants Monoclonal antibodies Mortality Nicotine Non-small cell lung carcinoma Pharmacology Plant Extracts - therapeutic use Plant Roots Proteins Review Scutellaria baicalensis Smoking Tumor necrosis factor-TNF |
| title | Scutellaria baicalensis and Their Natural Flavone Compounds as Potential Medicinal Drugs for the Treatment of Nicotine-Induced Non-Small-Cell Lung Cancer and Asthma |
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