Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequent...

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Veröffentlicht in:	Oncogene 2021-05, Vol.40 (21), p.3637-3654
Hauptverfasser:	Wanior, Marek, Krämer, Andreas, Knapp, Stefan, Joerger, Andreas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/555 631/154/556 631/337/100/102 631/337/176 631/67/1059/602 Adenosine triphosphatase Animals Antineoplastic Agents - pharmacology Apoptosis Cancer Cancer therapies Carcinogenesis Cell Biology Chimeras Chromatin Chromatin Assembly and Disassembly Chromatin remodeling Chromosomal Proteins, Non-Histone - antagonists & inhibitors Cyclin-dependent kinases Development and progression DNA probes Epigenetics Epigenomics Gene expression Gene regulation Genetic aspects Genetic transcription Genomes Genomics Human Genetics Humans Internal Medicine Kinases Lethality Medicine Medicine & Public Health Mutation Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Oncology, Experimental Proteins Proteolysis Regulatory proteins Review Review Article Structure Sucrose Transcription Transcription Factors - genetics Transcription Factors - metabolism Transcriptional coactivators
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