Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

Targeted protein degradation has emerged as a new paradigm to manipulate cellular proteostasis. Proteolysis-targeting chimeras (PROTACs) are bifunctional small molecules that recruit an E3 ligase to a target protein of interest, promoting its ubiquitination and subsequent degradation. Here, we repor...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-01, Vol.143 (2), p.593-598
Hauptverfasser:	Cotton, Adam D, Nguyen, Duy P, Gramespacher, Josef A, Seiple, Ian B, Wells, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antibodies - immunology B7-H1 Antigen - chemistry B7-H1 Antigen - immunology Communication Humans Proteolysis
Online-Zugang:	Volltext
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