Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also...
Gespeichert in:
| Veröffentlicht in: | International journal of environmental research and public health 2021-05, Vol.18 (10), p.5190 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 5190 |
| container_title | International journal of environmental research and public health |
| container_volume | 18 |
| creator | Biosca-Brull, Judit Pérez-Fernández, Cristian Mora, Santiago Carrillo, Beatriz Pinos, Helena Conejo, Nelida Maria Collado, Paloma Arias, Jorge L. Martín-Sánchez, Fernando Sánchez-Santed, Fernando Colomina, Maria Teresa |
| description | Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies. |
| doi_str_mv | 10.3390/ijerph18105190 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8153127</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2532494679</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-77f0ba739b252196b20b79a2101cbf63920ef57c04d49e3e8e9dcf2206bea05c3</originalsourceid><addsrcrecordid>eNpdkUFP3DAQRq2qqMC2V86WuPSyMLZjJ-4BaUVbQAKBoD1bjjPpepXYwU5A_PsGLULAaUaap6f59BFywOBICA3HfoNpWLOKgWQaPpE9phQsCwXs85t9l-znvAEQVaH0F7IrClAVl3KP3N9iZ0cfQ177gdY4PiIGuppGn3t6N6Ab09TTnz7H1GCiNjT0BvPonW8w_6AreveUR-xnhaO3-ODxkcaWnk-9DVs4oet88M529Co22OWvZKe1XcZvL3NB_v7-9ef0fHl5fXZxurpcOqHluCzLFmpbCl1zyZlWNYe61JYzYK5uldAcsJWlg6IpNAqsUDeu5RxUjRakEwtysvUOU91j4zCMyXZmSL636clE6837S_Br8y8-mIpJwXg5C76_CFK8n-bQpvfZYdfZgHHKhkuhioqXWszo4Qd0E6cU5njPFC90oWZsQY62lEsx54Tt6zMMzHOb5n2b4j9tr5O9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2532494679</pqid></control><display><type>article</type><title>Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>PubMed Central Open Access</source><creator>Biosca-Brull, Judit ; Pérez-Fernández, Cristian ; Mora, Santiago ; Carrillo, Beatriz ; Pinos, Helena ; Conejo, Nelida Maria ; Collado, Paloma ; Arias, Jorge L. ; Martín-Sánchez, Fernando ; Sánchez-Santed, Fernando ; Colomina, Maria Teresa</creator><creatorcontrib>Biosca-Brull, Judit ; Pérez-Fernández, Cristian ; Mora, Santiago ; Carrillo, Beatriz ; Pinos, Helena ; Conejo, Nelida Maria ; Collado, Paloma ; Arias, Jorge L. ; Martín-Sánchez, Fernando ; Sánchez-Santed, Fernando ; Colomina, Maria Teresa</creatorcontrib><description>Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph18105190</identifier><identifier>PMID: 34068255</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Animal cognition ; Autism ; Behavior ; Bias ; Chlorpyrifos ; Environmental factors ; Epidemiology ; Exposure ; Herbicides ; Insecticides ; Neurotoxicity ; Organic compounds ; Organophosphates ; Pesticides ; Prenatal experience ; Prenatal exposure ; Proteins ; Pyrethroids ; Review ; Rodents ; Stereotyped behavior ; Systematic review ; Urine</subject><ispartof>International journal of environmental research and public health, 2021-05, Vol.18 (10), p.5190</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-77f0ba739b252196b20b79a2101cbf63920ef57c04d49e3e8e9dcf2206bea05c3</citedby><cites>FETCH-LOGICAL-c395t-77f0ba739b252196b20b79a2101cbf63920ef57c04d49e3e8e9dcf2206bea05c3</cites><orcidid>0000-0002-7393-3675 ; 0000-0003-4749-5453 ; 0000-0002-5323-6602 ; 0000-0001-7386-8271 ; 0000-0002-2925-6806 ; 0000-0002-5619-4874 ; 0000-0003-2190-2006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153127/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153127/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Biosca-Brull, Judit</creatorcontrib><creatorcontrib>Pérez-Fernández, Cristian</creatorcontrib><creatorcontrib>Mora, Santiago</creatorcontrib><creatorcontrib>Carrillo, Beatriz</creatorcontrib><creatorcontrib>Pinos, Helena</creatorcontrib><creatorcontrib>Conejo, Nelida Maria</creatorcontrib><creatorcontrib>Collado, Paloma</creatorcontrib><creatorcontrib>Arias, Jorge L.</creatorcontrib><creatorcontrib>Martín-Sánchez, Fernando</creatorcontrib><creatorcontrib>Sánchez-Santed, Fernando</creatorcontrib><creatorcontrib>Colomina, Maria Teresa</creatorcontrib><title>Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models</title><title>International journal of environmental research and public health</title><description>Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.</description><subject>Animal cognition</subject><subject>Autism</subject><subject>Behavior</subject><subject>Bias</subject><subject>Chlorpyrifos</subject><subject>Environmental factors</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Herbicides</subject><subject>Insecticides</subject><subject>Neurotoxicity</subject><subject>Organic compounds</subject><subject>Organophosphates</subject><subject>Pesticides</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Proteins</subject><subject>Pyrethroids</subject><subject>Review</subject><subject>Rodents</subject><subject>Stereotyped behavior</subject><subject>Systematic review</subject><subject>Urine</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUFP3DAQRq2qqMC2V86WuPSyMLZjJ-4BaUVbQAKBoD1bjjPpepXYwU5A_PsGLULAaUaap6f59BFywOBICA3HfoNpWLOKgWQaPpE9phQsCwXs85t9l-znvAEQVaH0F7IrClAVl3KP3N9iZ0cfQ177gdY4PiIGuppGn3t6N6Ab09TTnz7H1GCiNjT0BvPonW8w_6AreveUR-xnhaO3-ODxkcaWnk-9DVs4oet88M529Co22OWvZKe1XcZvL3NB_v7-9ef0fHl5fXZxurpcOqHluCzLFmpbCl1zyZlWNYe61JYzYK5uldAcsJWlg6IpNAqsUDeu5RxUjRakEwtysvUOU91j4zCMyXZmSL636clE6837S_Br8y8-mIpJwXg5C76_CFK8n-bQpvfZYdfZgHHKhkuhioqXWszo4Qd0E6cU5njPFC90oWZsQY62lEsx54Tt6zMMzHOb5n2b4j9tr5O9</recordid><startdate>20210513</startdate><enddate>20210513</enddate><creator>Biosca-Brull, Judit</creator><creator>Pérez-Fernández, Cristian</creator><creator>Mora, Santiago</creator><creator>Carrillo, Beatriz</creator><creator>Pinos, Helena</creator><creator>Conejo, Nelida Maria</creator><creator>Collado, Paloma</creator><creator>Arias, Jorge L.</creator><creator>Martín-Sánchez, Fernando</creator><creator>Sánchez-Santed, Fernando</creator><creator>Colomina, Maria Teresa</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7393-3675</orcidid><orcidid>https://orcid.org/0000-0003-4749-5453</orcidid><orcidid>https://orcid.org/0000-0002-5323-6602</orcidid><orcidid>https://orcid.org/0000-0001-7386-8271</orcidid><orcidid>https://orcid.org/0000-0002-2925-6806</orcidid><orcidid>https://orcid.org/0000-0002-5619-4874</orcidid><orcidid>https://orcid.org/0000-0003-2190-2006</orcidid></search><sort><creationdate>20210513</creationdate><title>Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models</title><author>Biosca-Brull, Judit ; Pérez-Fernández, Cristian ; Mora, Santiago ; Carrillo, Beatriz ; Pinos, Helena ; Conejo, Nelida Maria ; Collado, Paloma ; Arias, Jorge L. ; Martín-Sánchez, Fernando ; Sánchez-Santed, Fernando ; Colomina, Maria Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-77f0ba739b252196b20b79a2101cbf63920ef57c04d49e3e8e9dcf2206bea05c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal cognition</topic><topic>Autism</topic><topic>Behavior</topic><topic>Bias</topic><topic>Chlorpyrifos</topic><topic>Environmental factors</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Herbicides</topic><topic>Insecticides</topic><topic>Neurotoxicity</topic><topic>Organic compounds</topic><topic>Organophosphates</topic><topic>Pesticides</topic><topic>Prenatal experience</topic><topic>Prenatal exposure</topic><topic>Proteins</topic><topic>Pyrethroids</topic><topic>Review</topic><topic>Rodents</topic><topic>Stereotyped behavior</topic><topic>Systematic review</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biosca-Brull, Judit</creatorcontrib><creatorcontrib>Pérez-Fernández, Cristian</creatorcontrib><creatorcontrib>Mora, Santiago</creatorcontrib><creatorcontrib>Carrillo, Beatriz</creatorcontrib><creatorcontrib>Pinos, Helena</creatorcontrib><creatorcontrib>Conejo, Nelida Maria</creatorcontrib><creatorcontrib>Collado, Paloma</creatorcontrib><creatorcontrib>Arias, Jorge L.</creatorcontrib><creatorcontrib>Martín-Sánchez, Fernando</creatorcontrib><creatorcontrib>Sánchez-Santed, Fernando</creatorcontrib><creatorcontrib>Colomina, Maria Teresa</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biosca-Brull, Judit</au><au>Pérez-Fernández, Cristian</au><au>Mora, Santiago</au><au>Carrillo, Beatriz</au><au>Pinos, Helena</au><au>Conejo, Nelida Maria</au><au>Collado, Paloma</au><au>Arias, Jorge L.</au><au>Martín-Sánchez, Fernando</au><au>Sánchez-Santed, Fernando</au><au>Colomina, Maria Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models</atitle><jtitle>International journal of environmental research and public health</jtitle><date>2021-05-13</date><risdate>2021</risdate><volume>18</volume><issue>10</issue><spage>5190</spage><pages>5190-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34068255</pmid><doi>10.3390/ijerph18105190</doi><orcidid>https://orcid.org/0000-0002-7393-3675</orcidid><orcidid>https://orcid.org/0000-0003-4749-5453</orcidid><orcidid>https://orcid.org/0000-0002-5323-6602</orcidid><orcidid>https://orcid.org/0000-0001-7386-8271</orcidid><orcidid>https://orcid.org/0000-0002-2925-6806</orcidid><orcidid>https://orcid.org/0000-0002-5619-4874</orcidid><orcidid>https://orcid.org/0000-0003-2190-2006</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2021-05, Vol.18 (10), p.5190 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8153127 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Animal cognition Autism Behavior Bias Chlorpyrifos Environmental factors Epidemiology Exposure Herbicides Insecticides Neurotoxicity Organic compounds Organophosphates Pesticides Prenatal experience Prenatal exposure Proteins Pyrethroids Review Rodents Stereotyped behavior Systematic review Urine |
| title | Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A54%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20Autism%20Spectrum%20Disorder%20and%20Pesticides:%20A%20Systematic%20Review%20of%20Human%20and%20Preclinical%20Models&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Biosca-Brull,%20Judit&rft.date=2021-05-13&rft.volume=18&rft.issue=10&rft.spage=5190&rft.pages=5190-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph18105190&rft_dat=%3Cproquest_pubme%3E2532494679%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2532494679&rft_id=info:pmid/34068255&rfr_iscdi=true |