Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated by complexes of 15-lipoxygenase (15-LOX) and a scaffold protein, phosphatidylethanolamine (PE)-binding protein (PEBP)1...

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Veröffentlicht in:	Nature chemical biology 2021-04, Vol.17 (4), p.465-476
Hauptverfasser:	Sun, Wan-Yang, Tyurin, Vladimir A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Anthonymuthu, Tamil S., Zhai, Yu-Jia, Pan, Ming-Hai, Gong, Hai-Biao, Lu, Dan-Hua, Sun, Jie, Duan, Wen-Jun, Korolev, Sergey, Abramov, Andrey Y., Angelova, Plamena R., Miller, Ian, Beharier, Ofer, Mao, Gao-Wei, Dar, Haider H., Kapralov, Alexandr A., Amoscato, Andrew A., Hastings, Teresa G., Greenamyre, Timothy J., Chu, Charleen T., Sadovsky, Yoel, Bahar, Ivet, Bayır, Hülya, Tyurina, Yulia Y., He, Rong-Rong, Kagan, Valerian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/80/82 631/92 631/92/287 Accumulation Basal ganglia Biochemical Engineering Biochemistry Bioorganic Chemistry Calcium ions Cell Biology Central nervous system diseases Chemistry Chemistry and Materials Science Chemistry/Food Science CRISPR Ferroptosis Fibroblasts Inactivation Lipids Lipoxygenase Liquid oxygen Movement disorders Mutants Mutation Neurodegeneration Neurodegenerative diseases Parkinson's disease Pathogenesis Phenotypes Phosphatidylethanolamine Phospholipase Phospholipids Proteins Rotenone Synuclein Thiols
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