Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores

Animal studies suggest that cochlear nerve degeneration precedes sensory cell degeneration in both noise-induced hearing loss (NIHL) and age-related hearing loss (ARHL), producing a hearing impairment that is not reflected in audiometric thresholds. Here, we investigated the histopathology of human...

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Veröffentlicht in:	The Journal of neuroscience 2021-05, Vol.41 (20), p.4439-4447
Hauptverfasser:	Wu, Pei-Zhe, O'Malley, Jennifer T, de Gruttola, Victor, Liberman, M Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse Age Aging Atrophy Auditory discrimination Auditory nerve Cochlea Degeneration Fibers Hair Hair cells Hearing Hearing loss Hearing protection High frequencies Histopathology Neurodegeneration Noise Regression models Stria vascularis
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