Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy
Purpose In facioscapulohumeral muscular dystrophy (FSHD) fatigue is a major complaint. We aimed to investigate whether during isometric sustained elbow flexions, performance fatigability indexes differ in patients with FSHD with respect to healthy controls. Methods Seventeen patients with FSHD and s...
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| Veröffentlicht in: | European journal of applied physiology 2021-06, Vol.121 (6), p.1617-1629 |
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| creator | Beretta-Piccoli, Matteo Calanni, Luca Negro, Massimo Ricci, Giulia Bettio, Cinzia Barbero, Marco Berardinelli, Angela Siciliano, Gabriele Tupler, Rossella Soldini, Emiliano Cescon, Corrado D’Antona, Giuseppe |
| description | Purpose
In facioscapulohumeral muscular dystrophy (FSHD) fatigue is a major complaint. We aimed to investigate whether during isometric sustained elbow flexions, performance fatigability indexes differ in patients with FSHD with respect to healthy controls.
Methods
Seventeen patients with FSHD and seventeen healthy controls performed two isometric flexions of the dominant biceps brachii at 20% of their maximal voluntary contraction (MVC) for 2 min and then at 60% MVC until exhaustion. Muscle weakness was characterized as a percentage of predicted values. Maximal voluntary strength, endurance time and performance fatigability indices (mean frequency of the power spectrum (MNF), muscle fiber conduction velocity (CV) and fractal dimension (FD)), extracted from the surface electromyogram signal (sEMG) were compared between the two groups.
Results
In patients with FSHD, maximal voluntary strength was 68.7% of predicted value (
p
|
| doi_str_mv | 10.1007/s00421-021-04650-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8144151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2494875281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-9292978454f76c1335554d3647e9e75dd27632b8a07b2332535d8ad94ed3e17f3</originalsourceid><addsrcrecordid>eNp9UU1r3DAQFaWlSZP-gR6KoZde3OjTsi-FEtI0EMilOQutNN5VsC1XIzfsv6_MJtuPQxGDRsybp_d4hLxj9BOjVF8gpZKzmq4lG0Vr8YKcMim6uhFcvzz2rDshbxAfKKUtZ-1rciJEIxvJ5SmxN5NLYBF8lQADZjs5qHJ8tMlj1dsctnYThpD3VZiqubxhylg9hrwrUxciOjsvQ9wtIyQ7VOOCbhlsqvwec4rzbn9OXvV2QHj7dJ-R-69X3y-_1bd31zeXX25rpzjPdcfL0a1UsteNY0IopaQvOjV0oJX3XBdXm9ZSveFCcCWUb63vJHgBTPfijHw-8M7LZgTvis4iyMwpjDbtTbTB_D2Zws5s40_TMimZYoXg4xNBij8WwGzGgA6GwU4QFzRcdrLVircr9MM_0Ie4pKnYM0UYK6kwTguKH1AuRcQE_VEMo2ZN0BwSNHStNUEjytL7P20cV54jKwBxAGAZTVtIv__-D-0veH2oOw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2531421120</pqid></control><display><type>article</type><title>Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy</title><source>Springer Nature - Complete Springer Journals</source><creator>Beretta-Piccoli, Matteo ; Calanni, Luca ; Negro, Massimo ; Ricci, Giulia ; Bettio, Cinzia ; Barbero, Marco ; Berardinelli, Angela ; Siciliano, Gabriele ; Tupler, Rossella ; Soldini, Emiliano ; Cescon, Corrado ; D’Antona, Giuseppe</creator><creatorcontrib>Beretta-Piccoli, Matteo ; Calanni, Luca ; Negro, Massimo ; Ricci, Giulia ; Bettio, Cinzia ; Barbero, Marco ; Berardinelli, Angela ; Siciliano, Gabriele ; Tupler, Rossella ; Soldini, Emiliano ; Cescon, Corrado ; D’Antona, Giuseppe</creatorcontrib><description><![CDATA[Purpose
In facioscapulohumeral muscular dystrophy (FSHD) fatigue is a major complaint. We aimed to investigate whether during isometric sustained elbow flexions, performance fatigability indexes differ in patients with FSHD with respect to healthy controls.
Methods
Seventeen patients with FSHD and seventeen healthy controls performed two isometric flexions of the dominant biceps brachii at 20% of their maximal voluntary contraction (MVC) for 2 min and then at 60% MVC until exhaustion. Muscle weakness was characterized as a percentage of predicted values. Maximal voluntary strength, endurance time and performance fatigability indices (mean frequency of the power spectrum (MNF), muscle fiber conduction velocity (CV) and fractal dimension (FD)), extracted from the surface electromyogram signal (sEMG) were compared between the two groups.
Results
In patients with FSHD, maximal voluntary strength was 68.7% of predicted value (
p
< 0.01). Compared to healthy controls, FSHD patients showed reduced MVC (
p
< 0.001;
r
= 0.62) and lower levels of performance fatigability, characterized by reduced rate of changes in MNF (
p
< 0.01;
r
= 0.56), CV (
p
< 0.05; 0.37) and FD (
p
< 0.001;
r
= 0.51) and increased endurance time (
p
< 0.001;
r
= 0.63), during the isometric contraction at 60% MVC.
Conclusion
A decreased reduction in the slopes of all the considered sEMG parameters during sustained isometric elbow flexions suggests that patients with FSHD experience lower levels of performance fatigability compared to healthy controls.]]></description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-021-04650-3</identifier><identifier>PMID: 33646424</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Contraction ; Elbow ; Electromyography ; Human Physiology ; Muscle contraction ; Muscular dystrophy ; Occupational Medicine/Industrial Medicine ; Original ; Original Article ; Sports Medicine</subject><ispartof>European journal of applied physiology, 2021-06, Vol.121 (6), p.1617-1629</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-9292978454f76c1335554d3647e9e75dd27632b8a07b2332535d8ad94ed3e17f3</citedby><cites>FETCH-LOGICAL-c522t-9292978454f76c1335554d3647e9e75dd27632b8a07b2332535d8ad94ed3e17f3</cites><orcidid>0000-0002-3797-1789 ; 0000-0002-9577-5567 ; 0000-0002-6142-2384 ; 0000-0003-4794-2540 ; 0000-0002-4645-8055 ; 0000-0001-8579-0686 ; 0000-0002-9159-9287 ; 0000-0002-1632-6684 ; 0000-0002-0683-5565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-021-04650-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-021-04650-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33646424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beretta-Piccoli, Matteo</creatorcontrib><creatorcontrib>Calanni, Luca</creatorcontrib><creatorcontrib>Negro, Massimo</creatorcontrib><creatorcontrib>Ricci, Giulia</creatorcontrib><creatorcontrib>Bettio, Cinzia</creatorcontrib><creatorcontrib>Barbero, Marco</creatorcontrib><creatorcontrib>Berardinelli, Angela</creatorcontrib><creatorcontrib>Siciliano, Gabriele</creatorcontrib><creatorcontrib>Tupler, Rossella</creatorcontrib><creatorcontrib>Soldini, Emiliano</creatorcontrib><creatorcontrib>Cescon, Corrado</creatorcontrib><creatorcontrib>D’Antona, Giuseppe</creatorcontrib><title>Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description><![CDATA[Purpose
In facioscapulohumeral muscular dystrophy (FSHD) fatigue is a major complaint. We aimed to investigate whether during isometric sustained elbow flexions, performance fatigability indexes differ in patients with FSHD with respect to healthy controls.
Methods
Seventeen patients with FSHD and seventeen healthy controls performed two isometric flexions of the dominant biceps brachii at 20% of their maximal voluntary contraction (MVC) for 2 min and then at 60% MVC until exhaustion. Muscle weakness was characterized as a percentage of predicted values. Maximal voluntary strength, endurance time and performance fatigability indices (mean frequency of the power spectrum (MNF), muscle fiber conduction velocity (CV) and fractal dimension (FD)), extracted from the surface electromyogram signal (sEMG) were compared between the two groups.
Results
In patients with FSHD, maximal voluntary strength was 68.7% of predicted value (
p
< 0.01). Compared to healthy controls, FSHD patients showed reduced MVC (
p
< 0.001;
r
= 0.62) and lower levels of performance fatigability, characterized by reduced rate of changes in MNF (
p
< 0.01;
r
= 0.56), CV (
p
< 0.05; 0.37) and FD (
p
< 0.001;
r
= 0.51) and increased endurance time (
p
< 0.001;
r
= 0.63), during the isometric contraction at 60% MVC.
Conclusion
A decreased reduction in the slopes of all the considered sEMG parameters during sustained isometric elbow flexions suggests that patients with FSHD experience lower levels of performance fatigability compared to healthy controls.]]></description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Contraction</subject><subject>Elbow</subject><subject>Electromyography</subject><subject>Human Physiology</subject><subject>Muscle contraction</subject><subject>Muscular dystrophy</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original</subject><subject>Original Article</subject><subject>Sports Medicine</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UU1r3DAQFaWlSZP-gR6KoZde3OjTsi-FEtI0EMilOQutNN5VsC1XIzfsv6_MJtuPQxGDRsybp_d4hLxj9BOjVF8gpZKzmq4lG0Vr8YKcMim6uhFcvzz2rDshbxAfKKUtZ-1rciJEIxvJ5SmxN5NLYBF8lQADZjs5qHJ8tMlj1dsctnYThpD3VZiqubxhylg9hrwrUxciOjsvQ9wtIyQ7VOOCbhlsqvwec4rzbn9OXvV2QHj7dJ-R-69X3y-_1bd31zeXX25rpzjPdcfL0a1UsteNY0IopaQvOjV0oJX3XBdXm9ZSveFCcCWUb63vJHgBTPfijHw-8M7LZgTvis4iyMwpjDbtTbTB_D2Zws5s40_TMimZYoXg4xNBij8WwGzGgA6GwU4QFzRcdrLVircr9MM_0Ie4pKnYM0UYK6kwTguKH1AuRcQE_VEMo2ZN0BwSNHStNUEjytL7P20cV54jKwBxAGAZTVtIv__-D-0veH2oOw</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Beretta-Piccoli, Matteo</creator><creator>Calanni, Luca</creator><creator>Negro, Massimo</creator><creator>Ricci, Giulia</creator><creator>Bettio, Cinzia</creator><creator>Barbero, Marco</creator><creator>Berardinelli, Angela</creator><creator>Siciliano, Gabriele</creator><creator>Tupler, Rossella</creator><creator>Soldini, Emiliano</creator><creator>Cescon, Corrado</creator><creator>D’Antona, Giuseppe</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3797-1789</orcidid><orcidid>https://orcid.org/0000-0002-9577-5567</orcidid><orcidid>https://orcid.org/0000-0002-6142-2384</orcidid><orcidid>https://orcid.org/0000-0003-4794-2540</orcidid><orcidid>https://orcid.org/0000-0002-4645-8055</orcidid><orcidid>https://orcid.org/0000-0001-8579-0686</orcidid><orcidid>https://orcid.org/0000-0002-9159-9287</orcidid><orcidid>https://orcid.org/0000-0002-1632-6684</orcidid><orcidid>https://orcid.org/0000-0002-0683-5565</orcidid></search><sort><creationdate>20210601</creationdate><title>Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy</title><author>Beretta-Piccoli, Matteo ; Calanni, Luca ; Negro, Massimo ; Ricci, Giulia ; Bettio, Cinzia ; Barbero, Marco ; Berardinelli, Angela ; Siciliano, Gabriele ; Tupler, Rossella ; Soldini, Emiliano ; Cescon, Corrado ; D’Antona, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-9292978454f76c1335554d3647e9e75dd27632b8a07b2332535d8ad94ed3e17f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Contraction</topic><topic>Elbow</topic><topic>Electromyography</topic><topic>Human Physiology</topic><topic>Muscle contraction</topic><topic>Muscular dystrophy</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original</topic><topic>Original Article</topic><topic>Sports Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beretta-Piccoli, Matteo</creatorcontrib><creatorcontrib>Calanni, Luca</creatorcontrib><creatorcontrib>Negro, Massimo</creatorcontrib><creatorcontrib>Ricci, Giulia</creatorcontrib><creatorcontrib>Bettio, Cinzia</creatorcontrib><creatorcontrib>Barbero, Marco</creatorcontrib><creatorcontrib>Berardinelli, Angela</creatorcontrib><creatorcontrib>Siciliano, Gabriele</creatorcontrib><creatorcontrib>Tupler, Rossella</creatorcontrib><creatorcontrib>Soldini, Emiliano</creatorcontrib><creatorcontrib>Cescon, Corrado</creatorcontrib><creatorcontrib>D’Antona, Giuseppe</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beretta-Piccoli, Matteo</au><au>Calanni, Luca</au><au>Negro, Massimo</au><au>Ricci, Giulia</au><au>Bettio, Cinzia</au><au>Barbero, Marco</au><au>Berardinelli, Angela</au><au>Siciliano, Gabriele</au><au>Tupler, Rossella</au><au>Soldini, Emiliano</au><au>Cescon, Corrado</au><au>D’Antona, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>121</volume><issue>6</issue><spage>1617</spage><epage>1629</epage><pages>1617-1629</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract><![CDATA[Purpose
In facioscapulohumeral muscular dystrophy (FSHD) fatigue is a major complaint. We aimed to investigate whether during isometric sustained elbow flexions, performance fatigability indexes differ in patients with FSHD with respect to healthy controls.
Methods
Seventeen patients with FSHD and seventeen healthy controls performed two isometric flexions of the dominant biceps brachii at 20% of their maximal voluntary contraction (MVC) for 2 min and then at 60% MVC until exhaustion. Muscle weakness was characterized as a percentage of predicted values. Maximal voluntary strength, endurance time and performance fatigability indices (mean frequency of the power spectrum (MNF), muscle fiber conduction velocity (CV) and fractal dimension (FD)), extracted from the surface electromyogram signal (sEMG) were compared between the two groups.
Results
In patients with FSHD, maximal voluntary strength was 68.7% of predicted value (
p
< 0.01). Compared to healthy controls, FSHD patients showed reduced MVC (
p
< 0.001;
r
= 0.62) and lower levels of performance fatigability, characterized by reduced rate of changes in MNF (
p
< 0.01;
r
= 0.56), CV (
p
< 0.05; 0.37) and FD (
p
< 0.001;
r
= 0.51) and increased endurance time (
p
< 0.001;
r
= 0.63), during the isometric contraction at 60% MVC.
Conclusion
A decreased reduction in the slopes of all the considered sEMG parameters during sustained isometric elbow flexions suggests that patients with FSHD experience lower levels of performance fatigability compared to healthy controls.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33646424</pmid><doi>10.1007/s00421-021-04650-3</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3797-1789</orcidid><orcidid>https://orcid.org/0000-0002-9577-5567</orcidid><orcidid>https://orcid.org/0000-0002-6142-2384</orcidid><orcidid>https://orcid.org/0000-0003-4794-2540</orcidid><orcidid>https://orcid.org/0000-0002-4645-8055</orcidid><orcidid>https://orcid.org/0000-0001-8579-0686</orcidid><orcidid>https://orcid.org/0000-0002-9159-9287</orcidid><orcidid>https://orcid.org/0000-0002-1632-6684</orcidid><orcidid>https://orcid.org/0000-0002-0683-5565</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2021-06, Vol.121 (6), p.1617-1629 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8144151 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences Biomedicine Contraction Elbow Electromyography Human Physiology Muscle contraction Muscular dystrophy Occupational Medicine/Industrial Medicine Original Original Article Sports Medicine |
| title | Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy |
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