Physical Stability and Dissolution of Lumefantrine Amorphous Solid Dispersions Produced by Spray Anti-Solvent Precipitation

This study aims to develop amorphous solid dispersion (ASD) of lumefantrine with a cost-effective approach of spray anti-solvent precipitation. Four acidic polymers, hydroxypropylmethylcellulose phthalate (HPMCP), hydroxypropylmethylcellulose acetate succinate (HPMCAS), poly(methacrylic acid–ethyl a...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2021-06, Vol.110 (6), p.2423-2431
Hauptverfasser:	Bhujbal, Sonal V., Pathak, Vaibhav, Zemlyanov, Dmitry Y., Taylor, Lynne S., Zhou, Qi (Tony)
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous solid dispersion Dissolution Moisture sorption Physical stability Precipitation
Online-Zugang:	Volltext
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