Survival and prognostic factors in patients with oral squamous cell carcinoma
This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analys...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2021-05, Vol.26 (3), p.e387-e392 |
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| container_title | Medicina oral, patología oral y cirugía bucal |
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| creator | Ferreira, A-K Carvalho, S-H Granville-Garcia, A-F Sarmento, D-J Agripino, G-G Abreu, M-H Melo, M-C Caldas, Jr, A-D Godoy, G-P |
| description | This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC).
Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients' prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors.
The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58).
OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis. |
| doi_str_mv | 10.4317/medoral.24242 |
| format | Article |
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Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients' prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors.
The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58).
OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.24242</identifier><identifier>PMID: 33037796</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Adult ; Brazil ; Carcinoma, Squamous Cell - therapy ; Dentistry ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms - therapy ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2021-05, Vol.26 (3), p.e387-e392</ispartof><rights>Copyright: © 2021 Medicina Oral S.L. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-88912b40f90ea9491495963502d38153a5675b70ecd9ab3d3cb120506ba8b4dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141315/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141315/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33037796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferreira, A-K</creatorcontrib><creatorcontrib>Carvalho, S-H</creatorcontrib><creatorcontrib>Granville-Garcia, A-F</creatorcontrib><creatorcontrib>Sarmento, D-J</creatorcontrib><creatorcontrib>Agripino, G-G</creatorcontrib><creatorcontrib>Abreu, M-H</creatorcontrib><creatorcontrib>Melo, M-C</creatorcontrib><creatorcontrib>Caldas, Jr, A-D</creatorcontrib><creatorcontrib>Godoy, G-P</creatorcontrib><title>Survival and prognostic factors in patients with oral squamous cell carcinoma</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC).
Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients' prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors.
The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58).
OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis.</description><subject>Adult</subject><subject>Brazil</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Dentistry</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Mouth Neoplasms - therapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUT1PwzAQtRCIlsLIijyypNixY8cLEqr4kooYgNlyHKc1SuLUTor497i0VEU33En3dO-9ewBcYjSlBPObxpTOq3qa0lhHYIyZyBMmKDs-mEfgLIRPhAjHnJ2CESFx5IKNwcvb4Nd2rWqo2hJ23i1aF3qrYaV073yAtoWd6q1p-wC_bL-EGzYYVoNq3BCgNnUNtfLatq5R5-CkUnUwF7s-AR8P9--zp2T--vg8u5snmuS8T_Jc4LSgqBLIKEEFpiITjGQoLUmOM6IyxrOCI6NLoQpSEl3gFGWIFSovaFmSCbjd3u2GIj5AR3VRley8bZT_lk5Z-X_T2qVcuLXMMcUkMkzA9e6Ad6vBhF42Nmy8qNZEWzKlVERFKeIRmmyh2rsQvKn2NBjJTQRyF4H8jSDirw617dF_Pyc_adGFBA</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Ferreira, A-K</creator><creator>Carvalho, S-H</creator><creator>Granville-Garcia, A-F</creator><creator>Sarmento, D-J</creator><creator>Agripino, G-G</creator><creator>Abreu, M-H</creator><creator>Melo, M-C</creator><creator>Caldas, Jr, A-D</creator><creator>Godoy, G-P</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210501</creationdate><title>Survival and prognostic factors in patients with oral squamous cell carcinoma</title><author>Ferreira, A-K ; Carvalho, S-H ; Granville-Garcia, A-F ; Sarmento, D-J ; Agripino, G-G ; Abreu, M-H ; Melo, M-C ; Caldas, Jr, A-D ; Godoy, G-P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-88912b40f90ea9491495963502d38153a5675b70ecd9ab3d3cb120506ba8b4dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Brazil</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Dentistry</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Mouth Neoplasms - therapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreira, A-K</creatorcontrib><creatorcontrib>Carvalho, S-H</creatorcontrib><creatorcontrib>Granville-Garcia, A-F</creatorcontrib><creatorcontrib>Sarmento, D-J</creatorcontrib><creatorcontrib>Agripino, G-G</creatorcontrib><creatorcontrib>Abreu, M-H</creatorcontrib><creatorcontrib>Melo, M-C</creatorcontrib><creatorcontrib>Caldas, Jr, A-D</creatorcontrib><creatorcontrib>Godoy, G-P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreira, A-K</au><au>Carvalho, S-H</au><au>Granville-Garcia, A-F</au><au>Sarmento, D-J</au><au>Agripino, G-G</au><au>Abreu, M-H</au><au>Melo, M-C</au><au>Caldas, Jr, A-D</au><au>Godoy, G-P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival and prognostic factors in patients with oral squamous cell carcinoma</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>26</volume><issue>3</issue><spage>e387</spage><epage>e392</epage><pages>e387-e392</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC).
Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients' prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors.
The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58).
OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>33037796</pmid><doi>10.4317/medoral.24242</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Brazil Carcinoma, Squamous Cell - therapy Dentistry Head and Neck Neoplasms Humans Mouth Neoplasms - therapy Prognosis Retrospective Studies Squamous Cell Carcinoma of Head and Neck |
| title | Survival and prognostic factors in patients with oral squamous cell carcinoma |
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