Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the (fibrillin-1) gene encoding a large glycoprotein in the extracellular matrix called fibrillin-1. The major complication of this connective disorder is the risk to develop thoracic aortic aneur...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2021-05, Vol.143 (21), p.2091-2109
Hauptverfasser:	Oller, Jorge, Gabandé-Rodríguez, Enrique, Ruiz-Rodríguez, María Jesús, Desdín-Micó, Gabriela, Aranda, Juan Francisco, Rodrigues-Diez, Raquel, Ballesteros-Martínez, Constanza, Blanco, Eva María, Roldan-Montero, Raquel, Acuña, Pedro, Forteza Gil, Alberto, Martín-López, Carlos E., Nistal, J. Francisco, Lino Cardenas, Christian L., Lindsay, Mark Evan, Martín-Ventura, José Luís, Briones, Ana M., Miguel Redondo, Juan, Mittelbrunn, María
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Aneurysm - physiopathology Disease Models, Animal Humans Marfan Syndrome - genetics Marfan Syndrome - physiopathology Mice Mitochondria - metabolism Original s
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