A Non-APOE Polygenic Risk Score for Alzheimer’s Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds

Abstract The effect of Alzheimer’s disease (AD) polygenic risk scores (PRS) on amyloid and tau pathophysiology and neurodegeneration in cognitively unimpaired older adults is not known in detail. This study aims to investigate non-APOE AD-PRS and APOE ε4 in relation to AD pathophysiology evaluated b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-05, Vol.76 (6), p.983-990
Hauptverfasser:	Skoog, Ingmar, Kern, Silke, Najar, Jenna, Guerreiro, Rita, Bras, Jose, Waern, Margda, Zetterberg, Henrik, Blennow, Kaj, Zettergren, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - genetics Alzheimer's disease Amyloid Amyloid beta-Peptides - cerebrospinal fluid Apolipoprotein E Biochips Biomarkers - cerebrospinal fluid Cerebrospinal fluid Dementia disorders Enzyme-linked immunosorbent assay Female Genetic Markers - genetics Genetic Predisposition to Disease - genetics Genotyping Humans Male Multifactorial Inheritance - genetics Neurodegeneration Neurodegenerative diseases Neurofilament Proteins - cerebrospinal fluid Neurogranin Neurogranin - cerebrospinal fluid Older people Peptide Fragments - cerebrospinal fluid Polymorphism Population genetics Professional football Risk Factors Tau protein tau Proteins - cerebrospinal fluid THE JOURNAL OF GERONTOLOGY: Biological Sciences
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!